iPTMnet Report for P31431 (SDC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31431 / SDC4_HUMAN
Protein Name Syndecan-4 precursor
Gene Name Name: SDC4
Organism Homo sapiens (Human)

PRO ID PR:P31431
DAG View
PRO Name syndecan-4 (human)
Definition A syndecan-4 that is encoded in the genome of human.
Short Label hSDC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31431 (SDC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T24 O-Glycosylation GlyGen 30459171
S95 O-Glycosylation GlyGen   UniProt 36213313, 32337544
S97 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T101 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K104 Ubiquitination PhosphoSitePlus
S117 O-Glycosylation PhosphoSitePlus
S126 O-Glycosylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S179 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 25260916, 12377772, 32404004
Y180 Phosphorylation PhosphoSitePlus   RLIMS-P 23453597
Y180 Phosphorylation P12931 (SRC) PhosphoSitePlus 23453597
K190 Ubiquitination PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 9556568, 11916978
S179 Phosphorylation P17252 (PRKCA) HPRD 11916978
S179 Phosphorylation Q05655 (PRKCD) HPRD 9556568, 11916978
Y197 Phosphorylation HPRD 17016520, 18083107, 17389395


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31431 (SDC4) Y180 O00560 (SDCBP) increased_association eFIP 23453597


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S95 Y95 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S117 P117 Biomuta [ cosmic ]
S179 G179 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]