Protein Information

Cytoscape View


UniProt AC / UniProt ID P30838 / AL3A1_HUMAN
Protein Name Aldehyde dehydrogenase, dimeric NADP-preferring
Gene Name Name: ALDH3A1
Synonyms:ALDH3;
Organism Homo sapiens (Human)

PRO ID PR:P30838
DAG View
PRO Name aldehyde dehydrogenase, dimeric NADP-preferring (human)
Definition An aldehyde dehydrogenase, dimeric NADP-preferring that is encoded in the genome of human.
Short Label hALDH3A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30838 (ALDH3A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
K3 Acetylation PhosphoSitePlus
S5 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y163 Phosphorylation PhosphoSitePlus
K178 Acetylation PhosphoSitePlus   UniProt 19608861
K178 Ubiquitination PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
K194 Acetylation PhosphoSitePlus   UniProt 19608861
T198 Phosphorylation PhosphoSitePlus
K202 Acetylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 G5 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T198 M198 Biomuta DOID:3070 / malignant glioma [ tcga ]
K202 E202 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T205 S205 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
Y272 C272 Biomuta DOID:1324 / lung cancer [ cosmic ]
K302 E302 Biomuta DOID:363 / uterine cancer [ tcga ]