iPTMnet Report P30793 GCH1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P30793 / GCH1_HUMAN
Protein Name	GTP cyclohydrolase 1
Gene Name	Name: GCH1 Synonyms:DYT5,GCH;
Organism	Homo sapiens (Human)

PRO ID	PR:P30793 DAG View
PRO Name	GTP cyclohydrolase 1 (human)
Definition	A GTP cyclohydrolase 1 that is encoded in the genome of human.
Short Label	hGCH1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P30793 (GCH1) as Substrate

Expanded View

Search:

	Site Select all By amino acid All Serine All Tyrosine By position K38 K54 S60 S81 K93 K160 Y175	PTM Type Select all Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3	Source Select all PhosphoSitePlus RLIMS-P UniProt	PMID
	K38	Ubiquitination		score1	PhosphoSitePlus
	K54	Ubiquitination		score1	PhosphoSitePlus
	S60	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332
	S81	Phosphorylation		score3	PhosphoSitePlus RLIMS-P UniProt	17704208
	K93	Ubiquitination		score1	PhosphoSitePlus
	K160	Ubiquitination		score1	PhosphoSitePlus
	Y175	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Serine All Tyrosine By position Y214 S223 S224	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all PhosphoSitePlus	PMID
	Y214	Phosphorylation		score1	PhosphoSitePlus
	S223	Phosphorylation		score1	PhosphoSitePlus
	S224	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position S223	Variant Select all Y223	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:363 / uterine cancer [ icgc ]
S223	Y223	Biomuta		DOID:363 / uterine cancer [ icgc ]