iPTMnet Report for P30307 (CDC25C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30307 / MPIP3_HUMAN
Protein Name M-phase inducer phosphatase 3
Gene Name Name: CDC25C
Organism Homo sapiens (Human)

PRO ID PR:P30307
DAG View
PRO Name M-phase inducer phosphatase 3 (human)
Definition An M-phase inducer phosphatase 3 that is encoded in the genome of human.
Short Label hCDC25C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30307 (CDC25C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S14 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S20 Phosphorylation PhosphoSitePlus   UniProt 23186163
K27 Ubiquitination PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S38 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T48 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 17382881, 23967052, ...25732194, 10037602, 8119945, 32075732, 27198502, 18669648, 26485758, 23707954, 27919943
T48 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 10037602, 8119945, 10864927
K52 Ubiquitination PhosphoSitePlus
S57 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S61 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
T67 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 10037602, 8119945, ...18669648, 20668692, 20068231
T67 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 10037602, 8119945, 10864927
K69 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus   RLIMS-P 27390173, 31537708
S122 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 10864927, 8119945
S122 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 10864927, 8119945
S129 Phosphorylation UniProt 12595692
T130 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 8119945, 20668692, ...12595692
T130 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 10864927, 8119945
S146 Phosphorylation PhosphoSitePlus
S148 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K151 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
S168 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 16964243, 10037602, ...22067460, 8119945, 20220133, 12742231
S168 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 10037602, 8119945
S168 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   Signor 20220133
S168 Phosphorylation P45984 (MAPK9) neXtProt   PhosphoSitePlus   Signor 12742231, 20220133
S168 Phosphorylation P53779 (MAPK10) Signor 20220133
T171 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
S191 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14968113
S191 Phosphorylation Q9H4B4 (PLK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14968113
S198 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32393310, 11897663, 19503101, ...18062778, 17706963, 14968113, 17634129
S198 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   Signor 11897663, 18062778
S198 Phosphorylation PR:P53350 (hPLK1) PRO 19503101
S198 Phosphorylation Q9H4B4 (PLK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14968113, 18062778
S207 Phosphorylation neXtProt   PhosphoSitePlus 14592973
S207 Phosphorylation P53778 (MAPK12) neXtProt 14592973
S209 Phosphorylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
S214 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 20530684, 29754473, ...8119945, 12766774, 10037602, 25506060
S214 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 10037602, 8119945, 12766774, ...10864927
S214 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 20530684
S216 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23967052, 16481012, 9836640, ...20143254, 10681541, 10786669, 28264028, 23451128, 29734760, 12569391, 27619510, 24505404, 21189416, 17237275, 24651441, 20564478, 22843362, 15791647, 24023871, 17989878, 30400903, 16794575, 19401701, 20637859, 29439343, 27603133, 10557092, 18159951, 10435585, 29071385, 10391675, 11027648, 18551195, 26799419, 15708996, 29467227, 26683224, 10744722, 15940258, 29754473, 24525428, 15629715, 25938491, 23186163, 15961392, 29774099, 9278511, 29680228, 9278512, 10444066, 19648910, 25544753, 27134571, 24643073, 22842784, 15736430, 11333986, 16582626, 17329004, 12835754, 10097108, 23733185, 25573277, 29039919, 14681223, 26699757, 11551930, 9543386, 21321122, 15282313, 17409144, 33718142, 18843201, 12766774, 15073169, 32311864, 32393310, 17630511, 26485758, 31285938, 15150265, 20068082, 25506060, 20500813, 33628174, 21624128, 25809478
S216 Phosphorylation O14757 (CHEK1) neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 25809478, 10681541, 10391675, ...9836640, 9278511, 14681223, 12766774, 9278512, 20068082, 10786669
S216 Phosphorylation O96017 (CHEK2) neXtProt   PhosphoSitePlus   Signor 12835754, 10097108, 10744722, ...16481012, 9836640, 16794575, 10786669
S216 Phosphorylation P27361 (MAPK3) RLIMS-P+ 16582626
S216 Phosphorylation P27448 (MARK3) PhosphoSitePlus 9543386, 10786669
S216 Phosphorylation P28482 (MAPK1) RLIMS-P+ 16582626
S216 Phosphorylation P43405 (SYK) RLIMS-P+ 25506060
S216 Phosphorylation P49137 (MAPKAPK2) neXtProt   PhosphoSitePlus 15629715
S216 Phosphorylation Q13237 (PRKG2) neXtProt 18551195
S216 Phosphorylation Q13535 (ATR) RLIMS-P+ 28264028
S216 Phosphorylation Q16512 (PKN1) neXtProt   Signor 15791647
S216 Phosphorylation Q16539 (MAPK14) neXtProt 11333986
S216 Phosphorylation Q683Z8 (CHK2) phospho.ELM 10744722, 9836640
S216 Phosphorylation Q8TDC3-2 (BRSK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15150265, 19648910, 9543386
S216 Phosphorylation Q9H4B4 (PLK3) neXtProt 10557092
K233 Ubiquitination PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 15064744
T236 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 15064744
K240 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus 23708659
S247 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 23708659
K251 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus   RLIMS-P 21189416, 17662724
S287 Phosphorylation RLIMS-P 25506060
K288 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus   UniProt 18691976
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 18691976
S15 Phosphorylation HPRD 18691976
S17 Phosphorylation HPRD 18669648
T37 Phosphorylation HPRD 18691976
S38 Phosphorylation HPRD 18669648
T48 Phosphorylation HPRD 18669648, 8119945
T48 Phosphorylation P06493 (CDK1) HPRD 18669648, 8119945
S57 Phosphorylation HPRD 18669648
S61 Phosphorylation HPRD 18669648, 20068231
S64 Phosphorylation HPRD 18691976, 18669648, 20068231
T67 Phosphorylation HPRD 18669648, 8119945, 20068231
T67 Phosphorylation P06493 (CDK1) HPRD 18669648, 8119945, 20068231
S122 Phosphorylation HPRD 8119945
S122 Phosphorylation P06493 (CDK1) HPRD 8119945
T130 Phosphorylation HPRD 8119945
T130 Phosphorylation P06493 (CDK1) HPRD 8119945
S148 Phosphorylation HPRD 18669648
S168 Phosphorylation HPRD 18691976, 8119945, 16964243, ...18212344
S168 Phosphorylation P06493 (CDK1) HPRD 18691976, 8119945, 16964243, ...18212344
S198 Phosphorylation HPRD 11897663
S198 Phosphorylation P53350 (PLK1) HPRD 11897663
S214 Phosphorylation HPRD 8119945
S214 Phosphorylation P06493 (CDK1) HPRD 8119945
S216 Phosphorylation HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation O14757 (CHEK1) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation O96017 (CHEK2) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation P27448 (MARK3) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation Q16512 (PKN1) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation Q16539 (MAPK14) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation Q8IWQ3 (BRSK2) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation Q8TDC3 (BRSK1) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S216 Phosphorylation Q9H4B4 (PLK3) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S472 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 18691976
S15 Phosphorylation HPRD 18691976
S17 Phosphorylation HPRD 18669648
T37 Phosphorylation HPRD 18691976
S38 Phosphorylation HPRD 18669648
T48 Phosphorylation HPRD 18669648
S61 Phosphorylation HPRD 18691976
S95 Phosphorylation HPRD 18691976, 16964243, 18212344
S143 Phosphorylation HPRD 20068231
S399 Phosphorylation HPRD 18691976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035546 (hCDC25C/Phos:1) pS198 PR:P53350 (hPLK1) PRO 19503101
PR:000046661 (hCDC25C/Phos:3) pS191 PRO