Protein Information

Cytoscape View


UniProt AC / UniProt ID P30307 / MPIP3_HUMAN
Protein Name M-phase inducer phosphatase 3
Gene Name Name: CDC25C
Organism Homo sapiens (Human)

PRO ID PR:P30307
DAG View
PRO Name M-phase inducer phosphatase 3 (human)
Definition An M-phase inducer phosphatase 3 that is encoded in the genome of human.
Short Label hCDC25C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30307 (CDC25C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S14 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S20 Phosphorylation PhosphoSitePlus   UniProt 23186163
K27 Ubiquitination PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S38 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T48 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 17382881, 23967052, ...25732194, 10037602, 8119945, 32075732, 27198502, 18669648, 26485758, 23707954, 27919943
K52 Ubiquitination PhosphoSitePlus
S57 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S61 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
T67 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 10037602, 8119945, ...18669648, 20668692, 20068231
K69 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus   RLIMS-P 27390173, 31537708
S122 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10864927, 8119945
S129 Phosphorylation UniProt 12595692
T130 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 8119945, 20668692, ...12595692
S146 Phosphorylation PhosphoSitePlus
S148 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K151 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
S168 Phosphorylation P45984 (MAPK9) , P53779 (MAPK10) , P45983 (MAPK8) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 16964243, 10037602, ...22067460, 8119945, 20220133, 12742231
T171 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
S191 Phosphorylation Q9H4B4 (PLK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14968113
S198 Phosphorylation Q9H4B4 (PLK3) , PR:P53350 (hPLK1) , P53350 (PLK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32393310, 11897663, 19503101, ...18404669, 18062778, 17706963, 14968113, 17634129
S207 Phosphorylation P53778 (MAPK12) neXtProt   PhosphoSitePlus 14592973
S209 Phosphorylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
S214 Phosphorylation P06493 (CDK1) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10864927, 20530684, 29754473, ...8119945, 12766774, 10037602, 25506060
S216 Phosphorylation P27361 (MAPK3) , Q13237 (PRKG2) , Q13535 (ATR) , Q683Z8 (CHK2) , P28482 (MAPK1) , P43405 (SYK) , P49137 (MAPKAPK2) , Q16512 (PKN1) , O14757 (CHEK1) , Q16539 (MAPK14) , Q9H4B4 (PLK3) , P27448 (MARK3) , Q8TDC3 (BRSK1) , O96017 (CHEK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23967052, 16481012, 9836640, ...20143254, 10681541, 10786669, 28264028, 23451128, 29734760, 12569391, 27619510, 24505404, 21189416, 17237275, 24651441, 20564478, 22843362, 15791647, 24023871, 17989878, 30400903, 16794575, 19401701, 20637859, 29439343, 27603133, 10557092, 18159951, 10435585, 10391675, 11027648, 31734829, 18551195, 26799419, 15708996, 29467227, 26683224, 10744722, 15940258, 29754473, 24525428, 15629715, 25938491, 23186163, 15961392, 29774099, 9278511, 29680228, 9278512, 10444066, 19648910, 25544753, 27134571, 24643073, 22842784, 15736430, 11333986, 16582626, 17329004, 12835754, 10097108, 23733185, 25573277, 29039919, 14681223, 26699757, 11551930, 9543386, 21321122, 15282313, 17409144, 33718142, 18843201, 12766774, 15073169, 32311864, 32393310, 17630511, 26485758, 31285938, 15150265, 20068082, 25506060, 20500813, 33628174, 21624128, 25809478, 33320980
K233 Ubiquitination PhosphoSitePlus
T236 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   Signor 15064744
K240 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S247 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 23708659
K251 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus   RLIMS-P 21189416, 17662724
S287 Phosphorylation RLIMS-P 25506060
K288 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus   UniProt 18691976
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 18691976
S15 Phosphorylation HPRD 18691976
S17 Phosphorylation HPRD 18669648
T37 Phosphorylation HPRD 18691976
S38 Phosphorylation HPRD 18669648
T48 Phosphorylation P06493 (CDK1) HPRD 18669648, 8119945
S57 Phosphorylation HPRD 18669648
S61 Phosphorylation HPRD 18669648, 20068231
S64 Phosphorylation HPRD 18691976, 18669648, 20068231
T67 Phosphorylation P06493 (CDK1) HPRD 18669648, 8119945, 20068231
S122 Phosphorylation P06493 (CDK1) HPRD 8119945
T130 Phosphorylation P06493 (CDK1) HPRD 8119945
S148 Phosphorylation HPRD 18669648
S168 Phosphorylation P06493 (CDK1) HPRD 18691976, 8119945, 16964243, ...18212344
S198 Phosphorylation P53350 (PLK1) HPRD 11897663
S214 Phosphorylation P06493 (CDK1) HPRD 8119945
S216 Phosphorylation Q8TDC3 (BRSK1) , O96017 (CHEK2) , Q8IWQ3 (BRSK2) , Q9H4B4 (PLK3) , P27448 (MARK3) , Q16539 (MAPK14) , Q16512 (PKN1) , O14757 (CHEK1) HPRD 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
S472 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 18691976
S15 Phosphorylation HPRD 18691976
S17 Phosphorylation HPRD 18669648
T37 Phosphorylation HPRD 18691976
S38 Phosphorylation HPRD 18669648
T48 Phosphorylation HPRD 18669648
S61 Phosphorylation HPRD 18691976
S95 Phosphorylation HPRD 18691976, 16964243, 18212344
S143 Phosphorylation HPRD 20068231
S399 Phosphorylation HPRD 18691976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035546 (hCDC25C/Phos:1) pS198 PR:P53350 (hPLK1) PRO 19503101
PR:000046661 (hCDC25C/Phos:3) pS191 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 P15 Biomuta DOID:263 / kidney cancer [ tcga ]
S17 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
K52 R52 Biomuta DOID:363 / uterine cancer [ tcga ]
S75 L75 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S122 R122 Biomuta DOID:363 / uterine cancer [ tcga ]
S198 F198 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S214 F214 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S247 F247 Biomuta DOID:1324 / lung cancer [ cosmic ]
K251 M251 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S263 F263 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K303 N303 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K317 T317 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]