iPTMnet Report P30281 CCND3

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P30281 / CCND3_HUMAN
Protein Name	G1/S-specific cyclin-D3
Gene Name	Name: CCND3
Organism	Homo sapiens (Human)

PRO ID	PR:P30281 DAG View
PRO Name	G1/S-specific cyclin-D3 (human)
Definition	A G1/S-specific cyclin-D3 that is encoded in the genome of human.
Short Label	hCCND3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P30281 (CCND3) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T9	Phosphorylation		score1	PhosphoSitePlus
	K123	Ubiquitination		score1	PhosphoSitePlus
	C189	Methylation		score1	IEDB	31844290
	T261	Phosphorylation		score1	PhosphoSitePlus
	S263	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
	S264	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
	S274	Phosphorylation		score1	PhosphoSitePlus
	S279	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332
	T281	Phosphorylation		score1	PhosphoSitePlus
	S282	Phosphorylation		score1	PhosphoSitePlus
	T283	Phosphorylation	P49841 (GSK3B) , Q15759 (MAPK11) , O15264 (MAPK13) , P53778 (MAPK12)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	15252116, 15326477, 17709384, ...16331257, 33122824
	T285	Phosphorylation		score1	PhosphoSitePlus
	T288	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S263	Phosphorylation		score0	HPRD	18669648
	S264	Phosphorylation		score0	HPRD	18669648

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T261	S261	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
S263	C263	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T283	N283	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
T283	I283	Biomuta		DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T283	A283	Biomuta		DOID:2531 / hematologic cancer [ cosmic, icgc ]
T283	P283	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]