iPTMnet Report for P29475 (NOS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29475 / NOS1_HUMAN
Protein Name Nitric oxide synthase 1
Gene Name Name: NOS1
Organism Homo sapiens (Human)

PRO ID PR:P29475
DAG View
PRO Name nitric oxide synthase, brain (human)
Definition A nitric oxide synthase, brain that is encoded in the genome of human.
Short Label hNOS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29475 (NOS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S292 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
T724 Phosphorylation PhosphoSitePlus
S746 Phosphorylation Q14012 (CAMK1) neXtProt 15251453
T766 Phosphorylation PhosphoSitePlus
T768 Phosphorylation PhosphoSitePlus
S852 Phosphorylation Q9UQM7 (CAMK2A) neXtProt   phospho.ELM   PhosphoSitePlus 10874031, 12630910, 10400690
S857 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus
S1082 O-Glycosylation GlyGen 30620550
T1358 Phosphorylation PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
S1387 Phosphorylation PhosphoSitePlus
S1417 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 11052978, 20585660, 26174015, ...26171233
Site PTM Type PTM Enzyme Score Source PMID
T396 Phosphorylation HPRD 18452278
S746 Phosphorylation Q14012 (CAMK1) HPRD 15251453
S852 Phosphorylation P17612 (PRKACA) , Q14012 (CAMK1) , P17252 (PRKCA) , Q16566 (CAMK4) , Q9UQM7 (CAMK2A) HPRD 10874031, 12630910, 1375933, ...10400690
S1417 Phosphorylation HPRD 11052978


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P98161 (PKD1) S916 P29475 (NOS1) unknown eFIP 24740233


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S292 F292 Biomuta DOID:363 / uterine cancer [ icgc ]
T396 A396 Biomuta DOID:3571 / liver cancer [ cosmic ]
S397 R397 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y453 N453 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T724 N724 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S746 W746 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T766 I766 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S857 Y857 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3953 / adrenal gland cancer [ cosmic ]
S859 F859 Biomuta [ cosmic ]
S1378 L1378 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1387 T1387 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1417 F1417 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]