iPTMnet Report for P29475 (NOS1)
Protein Information
| UniProt AC / UniProt ID | P29475 / NOS1_HUMAN |
| Protein Name | Nitric oxide synthase 1 |
| Gene Name | Name: NOS1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P29475 |
| PRO Name | nitric oxide synthase, brain (human) |
| Definition | A nitric oxide synthase, brain that is encoded in the genome of human. |
| Short Label | hNOS1 |
| Category | organism-gene |
DAG ViewP29475 (NOS1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S292 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T395 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T396 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S397 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y453 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y609 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T724 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S746 | Phosphorylation | score2 | neXtProt | 15251453 | ||
| S746 | Phosphorylation | Q14012 (CAMK1) | score2 | neXtProt | 15251453 | |
| T766 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T768 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S852 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus | 10874031, 12630910, 10400690 | ||
| S852 | Phosphorylation | Q9UQM7 (CAMK2A) | score3 | neXtProt | 10874031, 12630910 | |
| S857 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S859 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S885 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1082 | O-Glycosylation | score1 | GlyGen | 30620550 | ||
| T1358 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1387 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1417 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 11052978, 20585660, 26174015, ... |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T396 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S746 | Phosphorylation | score1 | HPRD | 15251453 | ||
| S746 | Phosphorylation | Q14012 (CAMK1) | score1 | HPRD | 15251453 | |
| S852 | Phosphorylation | score2 | HPRD | 10874031, 12630910, 1375933, ... | ||
| S852 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 10874031, 12630910, 1375933, ... | |
| S852 | Phosphorylation | P17612 (PRKACA) | score2 | HPRD | 10874031, 12630910, 1375933, ... | |
| S852 | Phosphorylation | Q14012 (CAMK1) | score2 | HPRD | 10874031, 12630910, 1375933, ... | |
| S852 | Phosphorylation | Q16566 (CAMK4) | score2 | HPRD | 10874031, 12630910, 1375933, ... | |
| S852 | Phosphorylation | Q9UQM7 (CAMK2A) | score2 | HPRD | 10874031, 12630910, 1375933, ... | |
| S1417 | Phosphorylation | score1 | HPRD | 11052978 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P98161 (PKD1) | S916 | P29475 (NOS1) | unknown | eFIP | 24740233 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S292 | F292 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T396 | A396 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S397 | R397 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| Y453 | N453 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| T724 | N724 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S746 | W746 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| T766 | I766 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S857 | Y857 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3953 / adrenal gland cancer [ cosmic ] | |
| S859 | F859 | Biomuta | [ cosmic ] | |
| S1378 | L1378 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S1387 | T1387 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S1417 | F1417 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] |
