iPTMnet Report for P29353 (SHC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29353 / SHC1_HUMAN
Protein Name SHC-transforming protein 1
Gene Name Name: SHC1
Synonyms:SHC,SHCA;
Organism Homo sapiens (Human)

PRO ID PR:P29353
DAG View
PRO Name SHC-transforming protein 1 (human)
Definition An shc-transforming protein 1 that is encoded in the genome of human.
Short Label hSHC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29353 (SHC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
M1 Acetylation UniProt 22814378
S28 Phosphorylation Q05655 (PRKCD) Signor 16963224
S36 Phosphorylation P45984 (MAPK9) , P53779 (MAPK10) , P05771 (PRKCB) , Q16539 (MAPK14) , P27361 (MAPK3) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15930121, 11602589, 15837797, ...20685851
S54 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus 16251354
T56 Phosphorylation Q16539 (MAPK14) neXtProt 16251354
S115 Phosphorylation PhosphoSitePlus
S139 Phosphorylation Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 17081983, ...16963224, 18669648, 24275569
K143 Ubiquitination PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
Y315 Phosphorylation Q05397 (PTK2) neXtProt   PhosphoSitePlus 9566877
K321 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation P12931 (SRC) , P06241 (FYN) , P43405 (SYK) , P35916 (FLT4) , P43403 (ZAP70) , P36888 (FLT3) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11075717, 10891441, 9566877, ...8939605, 10482988, 11687594, 9121430, 15592455, 9710204, 9927207, 28492659, 9872323
Y350 Phosphorylation P36888 (FLT3) , P12931 (SRC) , P06241 (FYN) , P35916 (FLT4) , P43405 (SYK) , P43403 (ZAP70) phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 11075717, 9710204, 8939605, ...9566877, 10482988, 9121430, 15592455, 9927207
T386 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus 16251354
S426 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y427 Phosphorylation P08581 (MET) , P06239 (LCK) , P35916 (FLT4) , P06241 (FYN) , P12931 (SRC) , P36888 (FLT3) , P43405 (SYK) , Q05397 (PTK2) , P43403 (ZAP70) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 9973396, 9710204, 9741627, ...22057045, 9083103, 12522270, 9927207, 8995379, 9254595, 23186163, 11827484, 8939605, 8940013, 9121430, 19690332, 11075717, 9566877, 12213123, 15592455, 8663178, 9175774, 8084588, 10482988, 7731718, 18083107, 18669648, 8610109, 9872323
K435 Ubiquitination PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus   UniProt 23186163
K462 Ubiquitination PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S139 Phosphorylation P17252 (PRKCA) HPRD 19651622, 18669648, 12052829, ...17924679
T145 Phosphorylation HPRD 17081983
Y349 Phosphorylation P12931 (SRC) , P43403 (ZAP70) , P43405 (SYK) HPRD 17016520, 19901323, 17389395, ...15688026, 16497976, 20068231, 9685404
Y350 Phosphorylation P43405 (SYK) , P43403 (ZAP70) , P12931 (SRC) HPRD 19901323, 17389395, 15688026, ...16497976, 20068231, 9685404
S426 Phosphorylation HPRD 18669648
Y427 Phosphorylation P06213 (INSR) , P43403 (ZAP70) , P06239 (LCK) , P06241 (FYN) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 16963224
Y239 Phosphorylation P43405 (SYK) , P06239 (LCK) , P43403 (ZAP70) , P00533 (EGFR) neXtProt   PhosphoSitePlus 9388490, 9685404, 9710204, ...17537990
Y240 Phosphorylation P06239 (LCK) , P43405 (SYK) , P43403 (ZAP70) , P00533 (EGFR) neXtProt   PhosphoSitePlus 9388490, 9685404, 9710204, ...17537990
Y317 Phosphorylation P00533 (EGFR) , P43403 (ZAP70) , P04629 (NTRK1) , P43405 (SYK) , P06239 (LCK) neXtProt   PhosphoSitePlus 9388490, 9710204, 12237775, ...17537990
Y410 Phosphorylation P52333 (JAK3) PhosphoSitePlus 24795043
Y448 Phosphorylation P52333 (JAK3) PhosphoSitePlus 24795043
Site PTM Type PTM Enzyme Score Source PMID
Y194 Phosphorylation P00533 (EGFR) , P12931 (SRC) PhosphoSitePlus 9388490
Y195 Phosphorylation P12931 (SRC) , P00533 (EGFR) PhosphoSitePlus 9388490
Y272 Phosphorylation P00533 (EGFR) , P12931 (SRC) PhosphoSitePlus 9388490
Site PTM Type PTM Enzyme Score Source PMID
Y428 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation P17252 (PRKCA) HPRD 19651622, 18669648, 12052829, ...17924679
T35 Phosphorylation HPRD 17081983
Y239 Phosphorylation P43405 (SYK) , P43403 (ZAP70) , P12931 (SRC) , P36888 (FLT3) HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
Y240 Phosphorylation P43403 (ZAP70) , P12931 (SRC) , P36888 (FLT3) , P43405 (SYK) HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
S317 Phosphorylation HPRD 18669648
Y318 Phosphorylation P36888 (FLT3) , P06239 (LCK) , P06241 (FYN) , P06213 (INSR) HPRD   PhosphoSitePlus 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231


P29353 (SHC1) as PTM Enzyme



Substrate Site Score Source PMID
P43403-2 (ZAP70) Y167 HPRD 7961936


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049230 (hSHC1/Phos:1) pY349,pY350 PRO
PR:000049231 (hSHC1/Phos:2) pY349,pY350,pY427 PRO
PR:000049232 (hSHC1/Phos:3) pY427 PRO
PR:000049233 (hSHC1/PhosTyr+) p PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025639 (hPEAR1/iso:1/Phos:1) Interaction PR:P29353 (hSHC1) PRO 15851471


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 A28 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T35 P35 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T145 P145 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y162 C162 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T206 P206 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S317 C317 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S317 P317 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S426 P426 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S426 C426 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S494 R494 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S513 N513 Biomuta DOID:363 / uterine cancer [ icgc ]