iPTMnet Report for P29353 (SHC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29353 / SHC1_HUMAN
Protein Name SHC-transforming protein 1
Gene Name Name: SHC1
Synonyms:SHC,SHCA;
Organism Homo sapiens (Human)

PRO ID PR:P29353
DAG View
PRO Name SHC-transforming protein 1 (human)
Definition An shc-transforming protein 1 that is encoded in the genome of human.
Short Label hSHC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29353 (SHC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
M1 Acetylation UniProt 22814378
S28 Phosphorylation Signor 16963224
S28 Phosphorylation Q05655 (PRKCD) Signor 16963224
S36 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15930121, 11602589, 15837797, ...20685851
S36 Phosphorylation P05771 (PRKCB) neXtProt 20685851
S36 Phosphorylation P27361 (MAPK3) neXtProt 15930121
S36 Phosphorylation P45983 (MAPK8) neXtProt 11602589
S36 Phosphorylation P45984 (MAPK9) neXtProt 11602589
S36 Phosphorylation P53779 (MAPK10) neXtProt 11602589
S36 Phosphorylation Q16539 (MAPK14) neXtProt 11602589
S54 Phosphorylation phospho.ELM   PhosphoSitePlus 16251354
S54 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 16251354
T56 Phosphorylation neXtProt 16251354
T56 Phosphorylation Q16539 (MAPK14) neXtProt 16251354
S115 Phosphorylation PhosphoSitePlus
S139 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 17081983, ...16963224, 18669648, 24275569
S139 Phosphorylation Q05655 (PRKCD) neXtProt   Signor 16963224
K143 Ubiquitination PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
Y315 Phosphorylation neXtProt   PhosphoSitePlus 9566877
Y315 Phosphorylation Q05397 (PTK2) neXtProt 9566877
K321 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11075717, 10891441, 9566877, ...8939605, 10482988, 11687594, 9121430, 15592455, 9710204, 9927207, 28492659, 9872323
Y349 Phosphorylation P06241 (FYN) Signor 9710204
Y349 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 8939605
Y349 Phosphorylation P35916 (FLT4) phospho.ELM   Signor 9927207
Y349 Phosphorylation P36888 (FLT3) Signor 10482988
Y349 Phosphorylation P43403 (ZAP70) phospho.ELM   Signor 9710204
Y349 Phosphorylation P43405 (SYK) phospho.ELM   Signor 9710204
Y350 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 11075717, 9710204, 8939605, ...9566877, 10482988, 9121430, 15592455, 9927207
Y350 Phosphorylation P06241 (FYN) Signor 9710204
Y350 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 8939605
Y350 Phosphorylation P35916 (FLT4) phospho.ELM   Signor 9927207
Y350 Phosphorylation P36888 (FLT3) Signor 10482988
Y350 Phosphorylation P43403 (ZAP70) phospho.ELM   Signor 9710204
Y350 Phosphorylation P43405 (SYK) phospho.ELM   Signor 9710204
T386 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 16251354
T386 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 16251354
S426 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y427 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 9973396, 9710204, 9741627, ...22057045, 9083103, 12522270, 9927207, 8995379, 9254595, 23186163, 11827484, 8939605, 8940013, 9121430, 19690332, 11075717, 9566877, 12213123, 15592455, 8663178, 9175774, 8084588, 10482988, 7731718, 18083107, 18669648, 8610109, 9872323
Y427 Phosphorylation P06239 (LCK) Signor 9710204
Y427 Phosphorylation P06241 (FYN) Signor 9710204, 9741627
Y427 Phosphorylation P08581 (MET) neXtProt   PhosphoSitePlus 7731718
Y427 Phosphorylation P12931 (SRC) PhosphoSitePlus 8939605
Y427 Phosphorylation P35916 (FLT4) phospho.ELM   Signor 9927207
Y427 Phosphorylation P36888 (FLT3) Signor 10482988
Y427 Phosphorylation P43403 (ZAP70) phospho.ELM   Signor 9710204
Y427 Phosphorylation P43405 (SYK) phospho.ELM   Signor 9710204
Y427 Phosphorylation Q05397 (PTK2) Signor 9566877
K435 Ubiquitination PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus   UniProt 23186163
K462 Ubiquitination PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S139 Phosphorylation HPRD 19651622, 18669648, 12052829, ...17924679
S139 Phosphorylation P17252 (PRKCA) HPRD 19651622, 18669648, 12052829, ...17924679
T145 Phosphorylation HPRD 17081983
Y349 Phosphorylation HPRD 17016520, 19901323, 17389395, ...15688026, 16497976, 20068231, 9685404
Y349 Phosphorylation P12931 (SRC) HPRD 17016520, 19901323, 17389395, ...15688026, 16497976, 20068231, 9685404
Y349 Phosphorylation P43403 (ZAP70) HPRD 17016520, 19901323, 17389395, ...15688026, 16497976, 20068231, 9685404
Y349 Phosphorylation P43405 (SYK) HPRD 17016520, 19901323, 17389395, ...15688026, 16497976, 20068231, 9685404
Y350 Phosphorylation HPRD 19901323, 17389395, 15688026, ...16497976, 20068231, 9685404
Y350 Phosphorylation P12931 (SRC) HPRD 19901323, 17389395, 15688026, ...16497976, 20068231, 9685404
Y350 Phosphorylation P43403 (ZAP70) HPRD 19901323, 17389395, 15688026, ...16497976, 20068231, 9685404
Y350 Phosphorylation P43405 (SYK) HPRD 19901323, 17389395, 15688026, ...16497976, 20068231, 9685404
S426 Phosphorylation HPRD 18669648
Y427 Phosphorylation HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y427 Phosphorylation P06213 (INSR) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y427 Phosphorylation P06239 (LCK) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y427 Phosphorylation P06241 (FYN) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y427 Phosphorylation P43403 (ZAP70) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus 16963224
S29 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 16963224
Y239 Phosphorylation neXtProt   PhosphoSitePlus 9388490, 9685404, 9710204, ...17537990
Y239 Phosphorylation P00533 (EGFR) neXtProt 9388490
Y239 Phosphorylation P06239 (LCK) PhosphoSitePlus 17537990
Y239 Phosphorylation P43403 (ZAP70) neXtProt   PhosphoSitePlus 9710204, 9685404
Y239 Phosphorylation P43405 (SYK) PhosphoSitePlus 9710204
Y240 Phosphorylation neXtProt   PhosphoSitePlus 9388490, 9685404, 9710204, ...17537990
Y240 Phosphorylation P00533 (EGFR) neXtProt 9388490
Y240 Phosphorylation P06239 (LCK) PhosphoSitePlus 17537990
Y240 Phosphorylation P43403 (ZAP70) neXtProt   PhosphoSitePlus 9710204, 9685404
Y240 Phosphorylation P43405 (SYK) PhosphoSitePlus 9710204
Y317 Phosphorylation neXtProt   PhosphoSitePlus 9388490, 9710204, 12237775, ...17537990
Y317 Phosphorylation P00533 (EGFR) neXtProt 9388490
Y317 Phosphorylation P04629 (NTRK1) PhosphoSitePlus 12237775
Y317 Phosphorylation P06239 (LCK) PhosphoSitePlus 9710204, 17537990
Y317 Phosphorylation P43403 (ZAP70) PhosphoSitePlus 9710204
Y317 Phosphorylation P43405 (SYK) PhosphoSitePlus 9710204
Y410 Phosphorylation PhosphoSitePlus 24795043
Y410 Phosphorylation P52333 (JAK3) PhosphoSitePlus 24795043
Y448 Phosphorylation PhosphoSitePlus 24795043
Y448 Phosphorylation P52333 (JAK3) PhosphoSitePlus 24795043
Site PTM Type PTM Enzyme Score Source PMID
Y194 Phosphorylation PhosphoSitePlus 9388490
Y194 Phosphorylation P00533 (EGFR) PhosphoSitePlus 9388490
Y194 Phosphorylation P12931 (SRC) PhosphoSitePlus 9388490
Y195 Phosphorylation PhosphoSitePlus 9388490
Y195 Phosphorylation P00533 (EGFR) PhosphoSitePlus 9388490
Y195 Phosphorylation P12931 (SRC) PhosphoSitePlus 9388490
Y272 Phosphorylation PhosphoSitePlus 9388490
Y272 Phosphorylation P00533 (EGFR) PhosphoSitePlus 9388490
Y272 Phosphorylation P12931 (SRC) PhosphoSitePlus 9388490
Site PTM Type PTM Enzyme Score Source PMID
Y428 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 19651622, 18669648, 12052829, ...17924679
S29 Phosphorylation P17252 (PRKCA) HPRD 19651622, 18669648, 12052829, ...17924679
T35 Phosphorylation HPRD 17081983
Y239 Phosphorylation HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
Y239 Phosphorylation P12931 (SRC) HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
Y239 Phosphorylation P36888 (FLT3) HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
Y239 Phosphorylation P43403 (ZAP70) HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
Y239 Phosphorylation P43405 (SYK) HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
Y240 Phosphorylation HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
Y240 Phosphorylation P12931 (SRC) HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
Y240 Phosphorylation P36888 (FLT3) HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
Y240 Phosphorylation P43403 (ZAP70) HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
Y240 Phosphorylation P43405 (SYK) HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
S317 Phosphorylation HPRD 18669648
Y318 Phosphorylation HPRD   PhosphoSitePlus 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y318 Phosphorylation P06213 (INSR) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y318 Phosphorylation P06239 (LCK) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y318 Phosphorylation P06241 (FYN) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
Y318 Phosphorylation P36888 (FLT3) HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231


P29353 (SHC1) as PTM Enzyme



Substrate Site Score Source PMID
P43403-2 (ZAP70) Y167 HPRD 7961936


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049230 (hSHC1/Phos:1) pY349,pY350 PRO
PR:000049231 (hSHC1/Phos:2) pY349,pY350,pY427 PRO
PR:000049232 (hSHC1/Phos:3) pY427 PRO
PR:000049233 (hSHC1/PhosTyr+) p PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025639 (hPEAR1/iso:1/Phos:1) Interaction PR:P29353 (hSHC1) PRO 15851471


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 A28 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T35 P35 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T145 P145 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y162 C162 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T206 P206 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S317 C317 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S317 P317 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S426 P426 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S426 C426 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S494 R494 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S513 N513 Biomuta DOID:363 / uterine cancer [ icgc ]