iPTMnet Report P29320 EPHA3

Protein Information

UniProt AC / UniProt ID	P29320 / EPHA3_HUMAN
Protein Name	Ephrin type-A receptor 3 precursor
Gene Name	Name: EPHA3 Synonyms:ETK,ETK1,HEK,TYRO4;
Organism	Homo sapiens (Human)

PRO ID	PR:P29320 DAG View
PRO Name	ephrin type-A receptor 3 (human)
Definition	An ephrin type-A receptor 3 that is encoded in the genome of human.
Short Label	hEPHA3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P29320 (EPHA3) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S294 T432 T442 T485 S497 S498 Y561 Y570 T595 Y596 T601 Y602 K625 T654 K656 Y659 Y701 Y736 Y742 S768 Y779 T781 Y937 T974 S976	PTM Type Select all Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 3 4	Source Select all PRO PhosphoSitePlus RLIMS-P Signor UniProt phospho.ELM	PMID
S294	Phosphorylation		score1	PhosphoSitePlus
T432	Phosphorylation		score1	PhosphoSitePlus
T442	Phosphorylation		score1	PhosphoSitePlus
T485	Phosphorylation		score1	PhosphoSitePlus
S497	Phosphorylation		score1	PhosphoSitePlus
S498	Phosphorylation		score1	PhosphoSitePlus
Y561	Phosphorylation		score1	PhosphoSitePlus
Y570	Phosphorylation		score1	PhosphoSitePlus
T595	Phosphorylation		score1	PhosphoSitePlus
Y596	Phosphorylation	P29320 (EPHA3)	score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	11870224, 8622983, 14993233, ...18547520
T601	Phosphorylation		score1	PhosphoSitePlus
Y602	Phosphorylation	P29320 (EPHA3)	score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	14993233, 20697431, 18547520, ...11870224
K625	Ubiquitination		score1	PhosphoSitePlus
T654	Phosphorylation		score1	PhosphoSitePlus
K656	Ubiquitination		score1	PhosphoSitePlus
Y659	Phosphorylation		score1	PhosphoSitePlus
Y701	Phosphorylation	P29320 (EPHA3)	score3	PhosphoSitePlus UniProt	18547520
Y736	Phosphorylation		score1	PhosphoSitePlus
Y742	Phosphorylation		score1	PhosphoSitePlus
S768	Phosphorylation		score1	PhosphoSitePlus
Y779	Phosphorylation	P29320 (EPHA3)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	14993233, 26232493, 17192257, ...18083107, 11870224, 20697431
T781	Phosphorylation		score1	PhosphoSitePlus
Y937	Phosphorylation		score1	PhosphoSitePlus
T974	Phosphorylation		score1	PhosphoSitePlus
S976	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Tyrosine By position Y596 Y602 Y779	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
Y596	Phosphorylation	P29320 (EPHA3)	score1	HPRD	11870224
Y602	Phosphorylation	P29320 (EPHA3)	score1	HPRD	11870224
Y779	Phosphorylation	P29320 (EPHA3)	score1	HPRD	11870224

P29320 (EPHA3) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P29320 (EPHA3) P29320-1 (EPHA3) P40763-1 (STAT3)	Site Select all By amino acid All Tyrosine By position Y596 Y602 Y701 Y705 Y779	Score Select all 2 3	Source Select all HPRD Signor UniProt phospho.ELM	PMID
P29320-1 (EPHA3)	Y596	score3	HPRD Signor UniProt	11870224
P29320 (EPHA3)	Y602	score3	HPRD phospho.ELM Signor UniProt	11870224
P29320 (EPHA3)	Y701	score2	UniProt	18547520
P29320 (EPHA3)	Y779	score3	HPRD phospho.ELM Signor UniProt	11870224
P40763-1 (STAT3)	Y705	score2	HPRD	17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000047294 (hEPHA3/SigPep-/Phos:1)	Sites Select all pY596,pY602	PTM Enzyme	Source Select all PRO	PMID
	PR:000047294 (hEPHA3/SigPep-/Phos:1)	pY596,pY602		PRO

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S294 T432 T442 S497 S498 Y561 Y596 Y602 K625 T654 K656 Y736 S768 T781 Y937 T974 S976	Variant Select all * C602 C736 F561 F937 I432 I497 I654 K974 L768 L976 M442 M974 N561 N596 N602 N656 P768 R294 R498 R781 S654 T625	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:11615 / penile cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S294	R294	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T432	I432	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T442	M442	Biomuta	DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S497	I497	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S498	R498	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y561	N561	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y561	F561	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y596	N596	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
Y602	N602	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y602	C602	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K625	T625	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T654	S654	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T654	I654	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K656	N656	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
Y736	C736	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S768	L768	Biomuta	DOID:11615 / penile cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S768	P768	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T781	R781	Biomuta	DOID:3571 / liver cancer [ cosmic ]
Y937	F937	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y937	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T974	M974	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
T974	K974	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S976	L976	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P29320 (EPHA3)

Protein Information

Interactive Sequence View

P29320 (EPHA3) as Substrate

P29320 (EPHA3) as PTM Enzyme

Proteoforms

PTM sites affected in variants