Protein Information

Cytoscape View


UniProt AC / UniProt ID P29320 / EPHA3_HUMAN
Protein Name Ephrin type-A receptor 3 precursor
Gene Name Name: EPHA3
Synonyms:ETK,ETK1,HEK,TYRO4;
Organism Homo sapiens (Human)

PRO ID PR:P29320
DAG View
PRO Name ephrin type-A receptor 3 (human)
Definition An ephrin type-A receptor 3 that is encoded in the genome of human.
Short Label hEPHA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29320 (EPHA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S294 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
Y596 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11870224, 8622983, 14993233, ...18547520
Y596 Phosphorylation P29320 (EPHA3) Signor   UniProt 11870224
T601 Phosphorylation PhosphoSitePlus
Y602 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14993233, 20697431, 18547520, ...11870224
Y602 Phosphorylation P29320 (EPHA3) phospho.ELM   Signor   UniProt 11870224
K625 Ubiquitination PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
Y659 Phosphorylation PhosphoSitePlus
Y701 Phosphorylation PhosphoSitePlus   UniProt 18547520
Y701 Phosphorylation P29320 (EPHA3) UniProt 18547520
Y736 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
Y779 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14993233, 26232493, 17192257, ...18083107, 11870224, 20697431
Y779 Phosphorylation P29320 (EPHA3) phospho.ELM   Signor   UniProt 11870224
T781 Phosphorylation PhosphoSitePlus
Y937 Phosphorylation PhosphoSitePlus
T974 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y596 Phosphorylation HPRD 11870224
Y596 Phosphorylation P29320 (EPHA3) HPRD 11870224
Y602 Phosphorylation HPRD 11870224
Y602 Phosphorylation P29320 (EPHA3) HPRD 11870224
Y779 Phosphorylation HPRD 11870224
Y779 Phosphorylation P29320 (EPHA3) HPRD 11870224


P29320 (EPHA3) as PTM Enzyme



Substrate Site Score Source PMID
P29320-1 (EPHA3) Y596 HPRD   Signor   UniProt 11870224
P29320 (EPHA3) Y602 HPRD   phospho.ELM   Signor   UniProt 11870224
P29320 (EPHA3) Y701 UniProt 18547520
P29320 (EPHA3) Y779 HPRD   phospho.ELM   Signor   UniProt 11870224
P40763-1 (STAT3) Y705 HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047294 (hEPHA3/SigPep-/Phos:1) pY596,pY602 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96T51 (RUFY1) Y389 P29320 (EPHA3) unknown eFIP 11877430


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S294 R294 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
T432 I432 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T442 M442 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S497 I497 Biomuta DOID:1324 / lung cancer [ tcga ]
Y561 F561 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y596 N596 Biomuta DOID:1324 / lung cancer [ tcga ]
K625 T625 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K656 N656 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S768 P768 Biomuta DOID:1324 / lung cancer [ tcga ]
T781 R781 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y937 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T974 M974 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
T974 K974 Biomuta DOID:1324 / lung cancer [ cosmic ]