iPTMnet Report P29317 EPHA2

Protein Information

UniProt AC / UniProt ID	P29317 / EPHA2_HUMAN
Protein Name	Ephrin type-A receptor 2 precursor
Gene Name	Name: EPHA2 Synonyms:ECK;
Organism	Homo sapiens (Human)

PRO ID	PR:P29317 DAG View
PRO Name	ephrin type-A receptor 2 (human)
Definition	An ephrin type-A receptor 2 that is encoded in the genome of human.
Short Label	hEPHA2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P29317 (EPHA2) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y67 K136 K141 S153 S154 K162 S277 S373 S426 T429 S433 N435 T437 S570 Y575 S577 K578 S579 K583 K586 T587 Y588 T593 Y594 K603 C612 K617 Y628 K629 K639 K646 T647 K649 K655 Y685 K686 T692 Y694 S712 K728 Y735 S749 S756 S761 T771 Y772 T773 T774 S775 K778 S790 Y791 K828 S869 K873 S880 K882 T883 S892 S897 T898 S899 S901 S910 Y921 T922 Y930 K935 T940 K945 Y960 S961	PTM Type Select all N-Glycosylation O-Glycosylation Phosphorylation S-Nitrosylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen PRO PhosphoSitePlus RLIMS-P Signor UniProt dbSNO neXtProt phospho.ELM	PMID
Y67	Phosphorylation		score1	PhosphoSitePlus
K136	Ubiquitination		score1	PhosphoSitePlus
K141	Ubiquitination		score1	PhosphoSitePlus
S153	Phosphorylation		score1	PhosphoSitePlus
S154	Phosphorylation		score1	PhosphoSitePlus
K162	Ubiquitination		score1	PhosphoSitePlus
S277	O-Glycosylation		score1	GlyGen	25813380
S277	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	32005975
S373	Phosphorylation		score1	PhosphoSitePlus
S426	Phosphorylation		score1	PhosphoSitePlus
T429	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	32005975
S433	Phosphorylation		score1	PhosphoSitePlus
N435	N-Glycosylation		score2	GlyGen UniProt	23090970, 29741879, 23345538, ...19159218, 24190977
T437	Phosphorylation		score1	PhosphoSitePlus
S570	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648, 17192257, ...19369195
Y575	Phosphorylation	P29317 (EPHA2)	score4	phospho.ELM PhosphoSitePlus UniProt	18083107, 21538645, 23186163
S577	Phosphorylation		score1	PhosphoSitePlus
K578	Ubiquitination		score1	PhosphoSitePlus
S579	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976
K583	Ubiquitination		score1	PhosphoSitePlus
K586	Ubiquitination		score1	PhosphoSitePlus
T587	Phosphorylation		score1	PhosphoSitePlus
Y588	Phosphorylation	P29317 (EPHA2)	score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor	33879771, 28581527, 15951569, ...35970390, 29946230, 35124461, 18387945, 32005975, 31887630, 18083107, 33196021, 27246245, 32115889, 28883622, 29262644, 33833989, 21538645, 27742560, 33893375
T593	Phosphorylation		score1	PhosphoSitePlus
Y594	Phosphorylation	P12931 (SRC) , P29317 (EPHA2)	score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor	18387945, 21538645, 17192257, ...32165640, 18083107, 15951569, 32897354, 22570727, 24457997, 28636467
K603	Ubiquitination		score1	PhosphoSitePlus
C612	S-Nitrosylation		score0	dbSNO	2212679, 22126794
K617	Ubiquitination		score1	PhosphoSitePlus
Y628	Phosphorylation	P29317 (EPHA2)	score4	PhosphoSitePlus UniProt	19369195, 21538645
K629	Ubiquitination		score1	PhosphoSitePlus
K639	Ubiquitination		score1	PhosphoSitePlus
K646	Ubiquitination		score1	PhosphoSitePlus
T647	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 19369195
K649	Ubiquitination		score1	PhosphoSitePlus
K655	Ubiquitination		score1	PhosphoSitePlus
Y685	Phosphorylation		score1	PhosphoSitePlus
K686	Ubiquitination		score1	PhosphoSitePlus
T692	Phosphorylation		score1	PhosphoSitePlus
Y694	Phosphorylation	P29317 (EPHA2)	score2	PhosphoSitePlus	21538645
S712	Phosphorylation		score1	PhosphoSitePlus
K728	Ubiquitination		score1	PhosphoSitePlus
Y735	Phosphorylation	P29317 (EPHA2)	score4	PhosphoSitePlus Signor	21538645, 18387945
S749	Phosphorylation		score1	PhosphoSitePlus
S756	Phosphorylation		score1	PhosphoSitePlus
S761	Phosphorylation		score1	PhosphoSitePlus
T771	Phosphorylation		score1	PhosphoSitePlus
Y772	Phosphorylation	P29317 (EPHA2)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor	32848131, 31484920, 33196021, ...18387945, 33328764, 17192257, 18083107, 15951569, 24023389, 25478832, 26861043, 30222105, 27324091, 21538645
T773	Phosphorylation		score1	PhosphoSitePlus
T774	Phosphorylation		score1	PhosphoSitePlus
S775	Phosphorylation		score1	PhosphoSitePlus
K778	Ubiquitination		score1	PhosphoSitePlus
S790	Phosphorylation		score1	PhosphoSitePlus
Y791	Phosphorylation		score1	PhosphoSitePlus
K828	Sumoylation		score1	PhosphoSitePlus
S869	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
K873	Ubiquitination		score1	PhosphoSitePlus
S880	Phosphorylation		score1	PhosphoSitePlus
K882	Ubiquitination		score1	PhosphoSitePlus
T883	Phosphorylation		score0	RLIMS-P	27385333
S892	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18669648, 23186163, 32413552
S897	Phosphorylation	P51812 (RPS6KA3) , P31749 (AKT1) , Q15418 (RPS6KA1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	27326255, 32417448, 17192257, ...32376822, 28966234, 27281300, 35110502, 32750331, 23186163, 29048432, 35124461, 24486585, 27132626, 36063341, 32115889, 33893375, 27385333, 32413552, 26158630, 27742560, 25239188, 25344320, 32762307, 33196021, 19573808, 31160603, 35668076, 28957431, 27533087, 23315987, 30583071, 30412282, 31887630, 21408136, 18669648, 28705041, 23772378, 34484860, 29956803, 29351356
T898	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648, 17192257
S899	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S901	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18669648, 23186163, 17192257, ...27385333
S910	Phosphorylation		score1	PhosphoSitePlus
Y921	Phosphorylation	P29317 (EPHA2)	score4	phospho.ELM PhosphoSitePlus	15951569, 21538645
T922	Phosphorylation		score1	PhosphoSitePlus
Y930	Phosphorylation		score4	phospho.ELM PhosphoSitePlus UniProt	15951569, 23358419
K935	Ubiquitination		score1	PhosphoSitePlus
T940	Phosphorylation		score1	PhosphoSitePlus
K945	Ubiquitination		score1	PhosphoSitePlus
Y960	Phosphorylation	P29317 (EPHA2)	score2	PhosphoSitePlus	21538645
S961	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position N435 S570 Y575 S579 T587 Y588 T593 Y594 Y628 T647 T771 Y772 T773 T774 S790 S892 S897 T898 S899 S901 Y921 Y930 Y960	PTM Type Select all N-Glycosylation Phosphorylation	PTM Enzyme	Score Select all 0 1	Source Select all HPRD PRO	PMID
N435	N-Glycosylation		score1	PRO	23345538
S570	Phosphorylation	P29317 (EPHA2)	score0	HPRD	18691976, 18669648, 17192257
Y575	Phosphorylation		score0	HPRD	17016520, 18083107, 17389395, ...18691976, 18707149
S579	Phosphorylation		score0	HPRD	18691976
T587	Phosphorylation		score0	HPRD	18691976
Y588	Phosphorylation		score0	HPRD	17016520, 18691976, 18578522, ...17389395, 15951569, 18707149
T593	Phosphorylation		score0	HPRD	18691976
Y594	Phosphorylation		score0	HPRD	15951569, 18578522, 18691976, ...18707149
Y628	Phosphorylation		score0	HPRD	18691976, 18578522, 20068231
T647	Phosphorylation		score0	HPRD	18691976
T771	Phosphorylation		score0	HPRD	18691976
Y772	Phosphorylation		score0	HPRD	17016520, 18691976, 18578522, ...17389395, 15951569, 18707149, 20068231
T773	Phosphorylation		score0	HPRD	18578522
T774	Phosphorylation		score0	HPRD	18578522
S790	Phosphorylation		score0	HPRD	18691976
S892	Phosphorylation		score0	HPRD	18669648
S897	Phosphorylation	P29317 (EPHA2)	score0	HPRD	18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658, 20068231
T898	Phosphorylation	P29317 (EPHA2)	score0	HPRD	18691976, 18578522, 18669648, ...17192257
S899	Phosphorylation	P29317 (EPHA2)	score0	HPRD	19651622, 18691976, 18578522, ...18669648, 17192257
S901	Phosphorylation	P29317 (EPHA2)	score0	HPRD	18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658
Y921	Phosphorylation		score0	HPRD	15951569, 18578522
Y930	Phosphorylation		score0	HPRD	15951569
Y960	Phosphorylation		score0	HPRD	18578522, 18707149

P29317 (EPHA2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all O14493 (CLDN4) P29317 (EPHA2) P29317-1 (EPHA2)	Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y208 S570 Y575 Y588 Y594 Y628 Y694 Y735 Y772 S897 T898 S899 S901 Y921 Y960	Score Select all 0 2 3 4	Source Select all HPRD PhosphoSitePlus Signor neXtProt phospho.ELM	PMID
O14493 (CLDN4)	Y208	score3	neXtProt phospho.ELM PhosphoSitePlus	16236711
P29317-1 (EPHA2)	S570	score0	HPRD	18691976, 18669648, 17192257
P29317 (EPHA2)	Y575	score2	PhosphoSitePlus	21538645
P29317 (EPHA2)	Y588	score4	PhosphoSitePlus Signor	21538645, 18387945
P29317 (EPHA2)	Y594	score4	PhosphoSitePlus Signor	21538645, 18387945
P29317 (EPHA2)	Y628	score2	PhosphoSitePlus	21538645
P29317 (EPHA2)	Y694	score2	PhosphoSitePlus	21538645
P29317 (EPHA2)	Y735	score4	PhosphoSitePlus Signor	21538645, 18387945
P29317 (EPHA2)	Y772	score4	PhosphoSitePlus Signor	21538645, 18387945
P29317-1 (EPHA2)	S897	score0	HPRD	18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658, 20068231
P29317-1 (EPHA2)	T898	score0	HPRD	18691976, 18578522, 18669648, ...17192257
P29317-1 (EPHA2)	S899	score0	HPRD	19651622, 18691976, 18578522, ...18669648, 17192257
P29317-1 (EPHA2)	S901	score0	HPRD	18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658
P29317 (EPHA2)	Y921	score2	PhosphoSitePlus	21538645
P29317 (EPHA2)	Y960	score2	PhosphoSitePlus	21538645

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000047292 (hEPHA2/SigPep-/Phos:2)	Sites Select all pY588,pY594	PTM Enzyme	Source Select all PRO	PMID
	PR:000047292 (hEPHA2/SigPep-/Phos:2)	pY588,pY594		PRO

PTM-dependent PPI

Search:

PTM type Select all Phosphorylation	Substrate Select all P29317 (EPHA2)	Site Select all By amino acid All Serine By position S897	Interactant Select all P00533 (EGFR) P31749 (AKT1) Q07954 (LRP1) Q5VV41 (ARHGEF16)	Association type Select all increased_association unknown	Source Select all eFIP	PMID
Phosphorylation	P29317 (EPHA2)	S897	P31749 (AKT1)	unknown	eFIP	21408136
Phosphorylation	P29317 (EPHA2)	S897	Q07954 (LRP1)	unknown	eFIP	21408136
Phosphorylation	P29317 (EPHA2)	S897	Q5VV41 (ARHGEF16)	unknown	eFIP	23772378
Phosphorylation	P29317 (EPHA2)	S897	P00533 (EGFR)	increased_association	eFIP	35668076

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K141 S277 S426 Y575 K586 T587 Y628 K646 T647 Y735 S749 S790 S880 T898 S899 Y930 T940	Variant Select all A587 C575 C735 D930 F628 F790 F880 G899 I940 L277 M647 M898 N141 N586 N646 N749 R141 R426	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:184 / bone cancer [ cosmic ] DOID:2174 / ocular cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] [ cosmic ] [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K141	N141	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
K141	R141	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S277	L277	Biomuta	DOID:2174 / ocular cancer [ cosmic ]
S426	R426	Biomuta	DOID:3571 / liver cancer [ cosmic ]
Y575	C575	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K586	N586	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
T587	A587	Biomuta	DOID:184 / bone cancer [ cosmic ]
Y628	F628	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K646	N646	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T647	M647	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y735	C735	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S749	N749	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S790	F790	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S880	F880	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
T898	M898	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S899	G899	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
Y930	D930	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T940	I940	Biomuta	[ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P29317 (EPHA2)

Protein Information

Interactive Sequence View

P29317 (EPHA2) as Substrate

P29317 (EPHA2) as PTM Enzyme

Proteoforms

PTM-dependent PPI

PTM sites affected in variants