iPTMnet Report for P29317 (EPHA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29317 / EPHA2_HUMAN
Protein Name Ephrin type-A receptor 2 precursor
Gene Name Name: EPHA2
Synonyms:ECK;
Organism Homo sapiens (Human)

PRO ID PR:P29317
DAG View
PRO Name ephrin type-A receptor 2 (human)
Definition An ephrin type-A receptor 2 that is encoded in the genome of human.
Short Label hEPHA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29317 (EPHA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y67 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
S277 O-Glycosylation GlyGen 25813380
S277 Phosphorylation PhosphoSitePlus   RLIMS-P 32005975
S373 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus   RLIMS-P 32005975
S433 Phosphorylation PhosphoSitePlus
N435 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 23345538, ...19159218, 24190977
T437 Phosphorylation PhosphoSitePlus
S570 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 17192257, ...19369195
Y575 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 21538645, 23186163
Y575 Phosphorylation P29317 (EPHA2) PhosphoSitePlus 21538645
S577 Phosphorylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus   UniProt 18691976
K583 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 33879771, 28581527, 15951569, ...35970390, 29946230, 35124461, 18387945, 32005975, 31887630, 18083107, 33196021, 27246245, 32115889, 28883622, 29262644, 33833989, 21538645, 27742560, 33893375
Y588 Phosphorylation P29317 (EPHA2) PhosphoSitePlus   Signor 21538645, 18387945
T593 Phosphorylation PhosphoSitePlus
Y594 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 18387945, 21538645, 17192257, ...32165640, 18083107, 15951569, 32897354, 22570727, 24457997, 28636467
Y594 Phosphorylation P12931 (SRC) Signor 24457997
Y594 Phosphorylation P29317 (EPHA2) PhosphoSitePlus   Signor 21538645, 18387945
K603 Ubiquitination PhosphoSitePlus
C612 S-Nitrosylation dbSNO 2212679, 22126794
K617 Ubiquitination PhosphoSitePlus
Y628 Phosphorylation PhosphoSitePlus   UniProt 19369195, 21538645
Y628 Phosphorylation P29317 (EPHA2) PhosphoSitePlus 21538645
K629 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
K649 Ubiquitination PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
Y685 Phosphorylation PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
Y694 Phosphorylation PhosphoSitePlus 21538645
Y694 Phosphorylation P29317 (EPHA2) PhosphoSitePlus 21538645
S712 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
Y735 Phosphorylation PhosphoSitePlus   Signor 21538645, 18387945
Y735 Phosphorylation P29317 (EPHA2) PhosphoSitePlus   Signor 21538645, 18387945
S749 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
T771 Phosphorylation PhosphoSitePlus
Y772 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 32848131, 31484920, 33196021, ...18387945, 33328764, 17192257, 18083107, 15951569, 24023389, 25478832, 26861043, 30222105, 27324091, 21538645
Y772 Phosphorylation P29317 (EPHA2) PhosphoSitePlus   Signor 21538645, 18387945
T773 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
Y791 Phosphorylation PhosphoSitePlus
K828 Sumoylation PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus   UniProt 19369195
K873 Ubiquitination PhosphoSitePlus
S880 Phosphorylation PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
T883 Phosphorylation RLIMS-P 27385333
S892 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 32413552
S897 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27326255, 32417448, 17192257, ...32376822, 28966234, 27281300, 35110502, 32750331, 23186163, 29048432, 35124461, 24486585, 27132626, 36063341, 32115889, 33893375, 27385333, 32413552, 26158630, 27742560, 25239188, 25344320, 32762307, 33196021, 19573808, 31160603, 35668076, 28957431, 27533087, 23315987, 30583071, 30412282, 31887630, 21408136, 18669648, 28705041, 23772378, 34484860, 29956803, 29351356
S897 Phosphorylation P31749 (AKT1) PhosphoSitePlus 19573808
S897 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 26158630
S897 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 26158630
T898 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17192257
S899 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S901 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 17192257, ...27385333
S910 Phosphorylation PhosphoSitePlus
Y921 Phosphorylation phospho.ELM   PhosphoSitePlus 15951569, 21538645
Y921 Phosphorylation P29317 (EPHA2) PhosphoSitePlus 21538645
T922 Phosphorylation PhosphoSitePlus
Y930 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15951569, 23358419
K935 Ubiquitination PhosphoSitePlus
T940 Phosphorylation PhosphoSitePlus
K945 Ubiquitination PhosphoSitePlus
Y960 Phosphorylation PhosphoSitePlus 21538645
Y960 Phosphorylation P29317 (EPHA2) PhosphoSitePlus 21538645
S961 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N435 N-Glycosylation PRO 23345538
S570 Phosphorylation HPRD 18691976, 18669648, 17192257
S570 Phosphorylation P29317 (EPHA2) HPRD 18691976, 18669648, 17192257
Y575 Phosphorylation HPRD 17016520, 18083107, 17389395, ...18691976, 18707149
S579 Phosphorylation HPRD 18691976
T587 Phosphorylation HPRD 18691976
Y588 Phosphorylation HPRD 17016520, 18691976, 18578522, ...17389395, 15951569, 18707149
T593 Phosphorylation HPRD 18691976
Y594 Phosphorylation HPRD 15951569, 18578522, 18691976, ...18707149
Y628 Phosphorylation HPRD 18691976, 18578522, 20068231
T647 Phosphorylation HPRD 18691976
T771 Phosphorylation HPRD 18691976
Y772 Phosphorylation HPRD 17016520, 18691976, 18578522, ...17389395, 15951569, 18707149, 20068231
T773 Phosphorylation HPRD 18578522
T774 Phosphorylation HPRD 18578522
S790 Phosphorylation HPRD 18691976
S892 Phosphorylation HPRD 18669648
S897 Phosphorylation HPRD 18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658, 20068231
S897 Phosphorylation P29317 (EPHA2) HPRD 18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658, 20068231
T898 Phosphorylation HPRD 18691976, 18578522, 18669648, ...17192257
T898 Phosphorylation P29317 (EPHA2) HPRD 18691976, 18578522, 18669648, ...17192257
S899 Phosphorylation HPRD 19651622, 18691976, 18578522, ...18669648, 17192257
S899 Phosphorylation P29317 (EPHA2) HPRD 19651622, 18691976, 18578522, ...18669648, 17192257
S901 Phosphorylation HPRD 18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658
S901 Phosphorylation P29317 (EPHA2) HPRD 18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658
Y921 Phosphorylation HPRD 15951569, 18578522
Y930 Phosphorylation HPRD 15951569
Y960 Phosphorylation HPRD 18578522, 18707149


P29317 (EPHA2) as PTM Enzyme



Substrate Site Score Source PMID
O14493 (CLDN4) Y208 neXtProt   phospho.ELM   PhosphoSitePlus 16236711
P29317-1 (EPHA2) S570 HPRD 18691976, 18669648, 17192257
P29317 (EPHA2) Y575 PhosphoSitePlus 21538645
P29317 (EPHA2) Y588 PhosphoSitePlus   Signor 21538645, 18387945
P29317 (EPHA2) Y594 PhosphoSitePlus   Signor 21538645, 18387945
P29317 (EPHA2) Y628 PhosphoSitePlus 21538645
P29317 (EPHA2) Y694 PhosphoSitePlus 21538645
P29317 (EPHA2) Y735 PhosphoSitePlus   Signor 21538645, 18387945
P29317 (EPHA2) Y772 PhosphoSitePlus   Signor 21538645, 18387945
P29317-1 (EPHA2) S897 HPRD 18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658, 20068231
P29317-1 (EPHA2) T898 HPRD 18691976, 18578522, 18669648, ...17192257
P29317-1 (EPHA2) S899 HPRD 19651622, 18691976, 18578522, ...18669648, 17192257
P29317-1 (EPHA2) S901 HPRD 18691976, 18578522, 20058876, ...17192257, 19651622, 18669648, 19415658
P29317 (EPHA2) Y921 PhosphoSitePlus 21538645
P29317 (EPHA2) Y960 PhosphoSitePlus 21538645


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047292 (hEPHA2/SigPep-/Phos:2) pY588,pY594 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P29317 (EPHA2) S897 P31749 (AKT1) unknown eFIP 21408136
Phosphorylation P29317 (EPHA2) S897 Q07954 (LRP1) unknown eFIP 21408136
Phosphorylation P29317 (EPHA2) S897 Q5VV41 (ARHGEF16) unknown eFIP 23772378
Phosphorylation P29317 (EPHA2) S897 P00533 (EGFR) increased_association eFIP 35668076


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K141 N141 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K141 R141 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S277 L277 Biomuta DOID:2174 / ocular cancer [ cosmic ]
S426 R426 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y575 C575 Biomuta DOID:1324 / lung cancer [ cosmic ]
K586 N586 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T587 A587 Biomuta DOID:184 / bone cancer [ cosmic ]
Y628 F628 Biomuta DOID:3571 / liver cancer [ cosmic ]
K646 N646 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T647 M647 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y735 C735 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S749 N749 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S790 F790 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S880 F880 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T898 M898 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S899 G899 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y930 D930 Biomuta DOID:1324 / lung cancer [ cosmic ]
T940 I940 Biomuta [ cosmic ]