iPTMnet Report for P28562 (DUSP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P28562 / DUS1_HUMAN
Protein Name Dual specificity protein phosphatase 1
Gene Name Name: DUSP1
Synonyms:CL100;
Organism Homo sapiens (Human)

PRO ID PR:P28562
DAG View
PRO Name dual specificity protein phosphatase 1 (human)
Definition A dual specificity protein phosphatase 1 that is encoded in the genome of human.
Short Label hDUSP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28562 (DUSP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K57 Acetylation PR:000007102 (EP300) PRO 18504304
K57 Ubiquitination PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S131 Phosphorylation RLIMS-P 25799226
S140 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
C269 Methylation IEDB 31844290
K280 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S296 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16286470
S323 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16286470
S334 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus   RLIMS-P 25799226
S359 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24244156, 25799226, 10617468, ...24666281
S364 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24244156, 10617468


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028583 (hDUSP1/Ac:1) acK57 PR:000007102 (EP300) PRO 18504304


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S140 L140 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S146 T146 Biomuta DOID:1319 / brain cancer [ cosmic ]
K221 N221 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]