iPTMnet Report for P28562 (DUSP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P28562 / DUS1_HUMAN
Protein Name Dual specificity protein phosphatase 1
Gene Name Name: DUSP1
Synonyms:CL100;
Organism Homo sapiens (Human)

PRO ID PR:P28562
DAG View
PRO Name dual specificity protein phosphatase 1 (human)
Definition A dual specificity protein phosphatase 1 that is encoded in the genome of human.
Short Label hDUSP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28562 (DUSP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K57 Acetylation PRO 18504304
K57 Acetylation PR:000007102 (EP300) PRO 18504304
K57 Ubiquitination PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S131 Phosphorylation RLIMS-P 25799226
S140 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
C269 Methylation IEDB 31844290
K280 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S296 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16286470
S296 Phosphorylation P27361 (MAPK3) Signor 16286470
S296 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16286470
S323 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16286470
S323 Phosphorylation P27361 (MAPK3) Signor 16286470
S323 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16286470
S334 Phosphorylation PhosphoSitePlus   RLIMS-P 25799226
S334 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus 25799226
S359 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24244156, 25799226, 10617468, ...24666281
S359 Phosphorylation P27361 (MAPK3) Signor 10617468
S359 Phosphorylation P28482 (MAPK1) HPRD   Signor 10617468
S364 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24244156, 10617468
S364 Phosphorylation P27361 (MAPK3) HPRD   phospho.ELM   Signor 10617468
S364 Phosphorylation P28482 (MAPK1) Signor 10617468


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028583 (hDUSP1/Ac:1) acK57 PR:000007102 (EP300) PRO 18504304


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S140 L140 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S146 T146 Biomuta DOID:1319 / brain cancer [ cosmic ]
K221 N221 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]