iPTMnet Report for P27815 (PDE4A)
Protein Information
| UniProt AC / UniProt ID | P27815 / PDE4A_HUMAN |
| Protein Name | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
| Gene Name | Name: PDE4A Synonyms:DPDE2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P27815 |
| PRO Name | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (human) |
| Definition | A cAMP-specific 3',5'-cyclic phosphodiesterase 4A that is encoded in the genome of human. |
| Short Label | hPDE4A |
| Category | organism-gene |
DAG ViewP27815 (PDE4A) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S8 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S13 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S85 | Phosphorylation | score1 | PhosphoSitePlus | |||
| G119 | Phosphorylation | score2 | UniProt | 11566027 | ||
| L123 | Phosphorylation | score2 | UniProt | 11566027 | ||
| S145 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus | 12023945, 18220336 | ||
| S145 | Phosphorylation | P17612 (PRKACA) | score2 | PhosphoSitePlus | 12023945 | |
| S152 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 21323643, 18669648 | ||
| S152 | Phosphorylation | P49137 (MAPKAPK2) | score3 | neXtProt Signor | 21323643 | |
| S157 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S165 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
| T199 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S209 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T215 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T271 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S302 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S346 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K358 | Sumoylation | score1 | PhosphoSitePlus | |||
| K358 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T551 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S567 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S568 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S577 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S628 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S686 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 11566027 | ||
| S688 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 11566027 | ||
| S810 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S818 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T870 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S871 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S881 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T886 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S44 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S68 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S119 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S447 | Phosphorylation | score1 | HPRD | 11566027 | ||
| S449 | Phosphorylation | score1 | HPRD | 11566027 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S46 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S123 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S13 | F13 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S15 | L15 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| S209 | P209 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
| T551 | I551 | Biomuta | [ cosmic ] | |
| S818 | N818 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S881 | A881 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] |
