Protein Information

Cytoscape View


UniProt AC / UniProt ID P27815 / PDE4A_HUMAN
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Gene Name Name: PDE4A
Synonyms:DPDE2;
Organism Homo sapiens (Human)

PRO ID PR:P27815
DAG View
PRO Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A (human)
Definition A cAMP-specific 3',5'-cyclic phosphodiesterase 4A that is encoded in the genome of human.
Short Label hPDE4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27815 (PDE4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus   UniProt 23186163
S15 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S145 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus 12023945, 18220336
S152 Phosphorylation P49137 (MAPKAPK2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 21323643, 18669648
S157 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus   UniProt 19690332
T199 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus   UniProt 23186163
T215 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus   UniProt 23186163
K358 Sumoylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
T551 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus   UniProt 11566027
S688 Phosphorylation PhosphoSitePlus   UniProt 11566027
S810 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
T870 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
T886 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S447 Phosphorylation HPRD 11566027
S449 Phosphorylation HPRD 11566027
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 L15 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S209 P209 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
T551 I551 Biomuta DOID:1115 / sarcoma [ tcga ]