iPTMnet Report for P26045 (PTPN3)
Protein Information
| UniProt AC / UniProt ID | P26045 / PTN3_HUMAN |
| Protein Name | Tyrosine-protein phosphatase non-receptor type 3 |
| Gene Name | Name: PTPN3 Synonyms:PTPH1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P26045 |
| PRO Name | tyrosine-protein phosphatase non-receptor type 3 (human) |
| Definition | A tyrosine-protein phosphatase non-receptor type 3 that is encoded in the genome of human. |
| Short Label | hPTPN3 |
| Category | organism-gene |
DAG ViewP26045 (PTPN3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y244 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y324 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S329 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S335 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S357 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
| S359 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 18669648, 23186163, 9341175 | ||
| S359 | Phosphorylation | O43318 (MAP3K7) | score3 | PhosphoSitePlus Signor | 9341175 | |
| S367 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| S370 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S372 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T376 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| S381 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| S394 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S395 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S425 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S427 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S455 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S459 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P | 30875834, 22730326 | ||
| S459 | Phosphorylation | P53778 (MAPK12) | score3 | neXtProt PhosphoSitePlus | 22730326 | |
| S469 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K486 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S489 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K526 | Acetylation | score1 | PhosphoSitePlus | |||
| K677 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y682 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T684 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S835 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 9341175 | ||
| T887 | Phosphorylation | score1 | IEDB | 35494241 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y324 | Phosphorylation | score0 | HPRD | 19901323 | ||
| S357 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S359 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S367 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S370 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S372 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T376 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S381 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S394 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S395 | Phosphorylation | score0 | HPRD | 18669648 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S335 | L335 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ] | |
| S335 | W335 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S370 | F370 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S372 | F372 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S372 | Y372 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S425 | R425 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] |
