Protein Information

Cytoscape View

UniProt AC / UniProt ID P26045 / PTN3_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 3
Gene Name Name: PTPN3
Organism Homo sapiens (Human)

PRO ID PR:P26045
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 3 (human)
Definition A tyrosine-protein phosphatase non-receptor type 3 that is encoded in the genome of human.
Short Label hPTPN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P26045 (PTPN3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y244 Phosphorylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S357 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S359 Phosphorylation O43318 (MAP3K7) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 23186163, 9341175
S367 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S370 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S372 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T376 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S381 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S394 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S395 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S425 Phosphorylation PhosphoSitePlus   UniProt 24275569
S427 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S459 Phosphorylation P53778 (MAPK12) neXtProt   PhosphoSitePlus   RLIMS-P 30875834, 22730326
S469 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
K526 Acetylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S835 Phosphorylation phospho.ELM   PhosphoSitePlus 9341175
Site PTM Type PTM Enzyme Score Source PMID
Y324 Phosphorylation HPRD 19901323
S357 Phosphorylation HPRD 18669648
S359 Phosphorylation HPRD 18669648
S367 Phosphorylation HPRD 18669648
S370 Phosphorylation HPRD 18669648
S372 Phosphorylation HPRD 18669648
T376 Phosphorylation HPRD 18669648
S381 Phosphorylation HPRD 18669648
S394 Phosphorylation HPRD 18669648
S395 Phosphorylation HPRD 18669648

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S335 L335 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:3070 / malignant glioma [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S335 W335 Biomuta DOID:1612 / breast cancer [ tcga ]
S372 F372 Biomuta DOID:1909 / melanoma [ cosmic ]
S372 Y372 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S425 R425 Biomuta DOID:10283 / prostate cancer [ cosmic ]