iPTMnet Report for P25963 (NFKBIA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P25963 / IKBA_HUMAN
Protein Name NF-kappa-B inhibitor alpha
Gene Name Name: NFKBIA
Synonyms:IKBA,MAD3,NFKBI;
Organism Homo sapiens (Human)

PRO ID PR:P25963
DAG View
PRO Name NF-kappa-B inhibitor alpha (human)
Definition An NF-kappa-B inhibitor alpha that is encoded in the genome of human.
Short Label hNFKBIA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25963 (NFKBIA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K21 Sumoylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus   UniProt 10574930, 20347421, 7479976
K22 Sumoylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus   UniProt 10574930, 20347421, 7479976
S32 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23250755, 18657515, 15879144, ...23118497, 10336492, 18207244, 7796813, 12377412, 8887633, 16619039, 9346485, 10723127, 8655651, 20890592, 9789032, 11254493, 28431901, 10329681, 9914500, 10398585, 9244310, 23892407, 10982547, 11408488, 10973957, 9734360, 15368357, 10490984, 8622650, 15880609, 15093615, 8660357, 12909638, 10437795, 11815618, 9214631, 20385620, 18444250, 18468507, 9252186, 8631829, 17308110, 28467781, 10574930, 10918611, 33184242, 24552816, 9792644, 9346241, 16271147, 10823818, 9261139, 8657102, 29050234, 7878466, 9721103, 7479976, 10882136, 10930537, 26721416, 24083678, 12189195, 10527519, 9707608, 18455150, 16007147, 28629746, 8601309, 10421793, 10384135, 17409387, 10542212, 9346484, 16319058, 16822942, 10754328, 15695387, 9689078, 8604224, 15308505, 15128824, 12403772, 20191354, 19796012, 9154800, 33572115, 25881508, 9632633, 15843586, 7628694, 20811049, 21606193, 16015604, 9573057, 11994255, 30804118, 12138192, 18453612, 12054687, 18436431, 35081975, 11279241, 22896603, 10409681, 10593898, 11752211, 10066434
S32 Phosphorylation O00141 (SGK1) PhosphoSitePlus 15695387
S32 Phosphorylation O14920 (IKBKB) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+ 8601309, 17409387, 9214631, ...10823818, 9346484, 10723127, 9346485, 16319058, 9721103, 10882136
S32 Phosphorylation O14965 (AURKA) neXtProt 17308110
S32 Phosphorylation O15111 (CHUK) neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 9914500, 9244310, 10823818, ...10527519, 9346241, 9252186, 9346484, 11752211
S32 Phosphorylation P19525 (EIF2AK2) HPRD 8601309, 10723127, 9721103, ...9214631
S32 Phosphorylation P34947 (GRK5) neXtProt 19796012
S32 Phosphorylation P43250 (GRK6) RLIMS-P+ 25881508
S32 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 20385620
S32 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus 9914500, 10398585
S32 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus 10421793, 15879144, 10882136
S32 Phosphorylation Q15349 (RPS6KA2) Signor 20385620
S32 Phosphorylation Q15418 (RPS6KA1) HPRD   neXtProt   PhosphoSitePlus 8601309, 9914500, 9214631, ...9261139, 10723127, 16822942, 9721103
S32 Phosphorylation Q96KB5 (PBK) RLIMS-P+ 23250755
S32 Phosphorylation Q99558 (MAP3K14) PhosphoSitePlus 9707608
S32 Phosphorylation Q9Y6K9 (IKBKG) HPRD 16319058
S36 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 17308110, 11408488, 10823818, ...26721416, 10421793, 9154800, 11752211, 15368357, 10490984, 10542212, 18657515, 15879144, 8622650, 15880609, 23118497, 15843586, 10409681, 17409387, 8660357, 7628694, 12909638, 12377412, 10437795, 11815618, 18207244, 9734360, 16015604, 25881508, 7796813, 16271147, 10527519, 18444250, 30804118, 9707608, 8887633, 12138192, 18455150, 9346485, 9346484, 16007147, 8655651, 28629746, 8631829, 16619039, 8601309, 12054687, 9261139, 18436431, 9789032, 11279241, 11254493, 9346241, 10593898, 9214631, 9252186, 10574930, 10918611, 21606193, 10329681, 28467781, 16822942, 10754328, 9914500, 24552816, 9792644, 9689078, 9632633, 19796012, 10398585, 9244310, 15128824, 12403772, 8657102, 9632806, 10066434, 7878466, 23892407, 10783893, 9721103, 7479976, 10882136
S36 Phosphorylation O14920 (IKBKB) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+ 8601309, 10823818, 17409387, ...9346485, 9346484, 10882136, 9721103, 10783893
S36 Phosphorylation O14965 (AURKA) neXtProt 17308110
S36 Phosphorylation O15111 (CHUK) neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 9914500, 9244310, 10823818, ...10527519, 9346241, 9252186, 9346484, 11752211
S36 Phosphorylation P43250 (GRK6) RLIMS-P+ 25881508
S36 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus 10398585
S36 Phosphorylation Q14164 (IKBKE) HPRD   neXtProt   PhosphoSitePlus 10421793, 15879144, 10882136
S36 Phosphorylation Q15418 (RPS6KA1) neXtProt 9261139, 16822942, 9214631
S36 Phosphorylation Q99558 (MAP3K14) PhosphoSitePlus 9707608
S36 Phosphorylation Q9UHD2 (TBK1) HPRD   Signor 8601309, 9721103, 11815618, ...10783893
K38 Ubiquitination PhosphoSitePlus
Y42 Phosphorylation HPRD   IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 17533369, 11408488, 24101387, ...9892650, 8797825, 30464509, 12429743, 11231305, 8940099, 10722693, 12909638, 9792645, 19074556, 10754328, 12432072
Y42 Phosphorylation P06213 (INSR) PhosphoSitePlus 8797825
Y42 Phosphorylation P06239 (LCK) HPRD   phospho.ELM   PhosphoSitePlus 8797825, 12429743, 9792645
Y42 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   Signor 8797825, 12429743, 9792645
Y42 Phosphorylation P43405 (SYK) RLIMS-P+ 24101387
K47 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus   RLIMS-P 34030642
K67 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
T90 Phosphorylation HPRD   PhosphoSitePlus 20068231
K98 Ubiquitination PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
C186 Methylation IEDB 31844290
C215 Methylation IEDB 31844290
K238 Ubiquitination PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus   RLIMS-P 34030642
T273 Phosphorylation RLIMS-P 9632806
S283 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8657113, 11673497, 8622692
S283 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 8657113, 11673497, 8622692
S288 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8622692
S288 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 8622692
Y289 Phosphorylation PhosphoSitePlus
T291 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8657113, 11673497, 8622692, ...10398585
T291 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 8657113, 11673497, 8622692, ...10398585
S293 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12167702, 10764587, 8622692, ...8668171
S293 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 10764587, 8622692
T299 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 8657113, 11673497
T299 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 8657113, 11673497
Y305 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 12167702, 12909638, 14757045
Y305 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 14757045
Y305 Phosphorylation P00519 (ABL1) PhosphoSitePlus 12167702
Site PTM Type PTM Enzyme Score Source PMID
K21 Ubiquitination PRO 10329681
K22 Ubiquitination PRO 10329681
S32 Phosphorylation PRO 10329681
S32 Phosphorylation PR:000026457 (IkappaB kinase complex (human)) PRO 10329681
S36 Phosphorylation PRO 10329681
S36 Phosphorylation PR:000026457 (IkappaB kinase complex (human)) PRO 10329681


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048597 (hNFKBIA/UbiqLys+) ub PRO
PR:000028546 (hNFKBIA/iso:1/Phos:1) pS32,pS36 PR:000026457 (IkappaB kinase complex (human)) PRO 10329681
PR:000028548 (hNFKBIA/iso:1/PhosUbiq:1) ubK21,ubK22 PRO 10329681
PR:000028548 (hNFKBIA/iso:1/PhosUbiq:1) pS32,pS36 PRO 10329681


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P25963 (NFKBIA) S36 P19838 (NFKB1) unknown eFIP 15128824