Protein Information

Cytoscape View


UniProt AC / UniProt ID P25963 / IKBA_HUMAN
Protein Name NF-kappa-B inhibitor alpha
Gene Name Name: NFKBIA
Synonyms:IKBA,MAD3,NFKBI;
Organism Homo sapiens (Human)

PRO ID PR:P25963
DAG View
PRO Name NF-kappa-B inhibitor alpha (human)
Definition An NF-kappa-B inhibitor alpha that is encoded in the genome of human.
Short Label hNFKBIA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25963 (NFKBIA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K21 Sumoylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K22 Sumoylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus   UniProt 20347421, 7479976
S32 Phosphorylation O00141 (SGK1) , P68400 (CSNK2A1) , O14965 (AURKA) , Q99558 (MAP3K14) , P43250 (GRK6) , Q15418 (RPS6KA1) , Q14164 (IKBKE) , P19525 (EIF2AK2) , O15111 (CHUK) , Q96KB5 (PBK) , O14920 (IKBKB) , P51812 (RPS6KA3) , P34947 (GRK5) , Q9Y6K9 (IKBKG) , Q15349 (RPS6KA2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23250755, 23675531, 18657515, ...15879144, 10329681, 23118497, 10336492, 18207244, 28597146, 23559010, 7796813, 12377412, 8887633, 16619039, 9346485, 10723127, 8655651, 9789032, 11254493, 28431901, 26232502, 24957606, 9914500, 24675998, 9244310, 10545482, 23892407, 10982547, 23593410, 11408488, 10973957, 9734360, 15368357, 10490984, 8622650, 8604224, 15093615, 8660357, 12909638, 10437795, 11815618, 9214631, 24516376, 20385620, 18444250, 18468507, 26930276, 9252186, 17308110, 28467781, 16818647, 10574930, 10918611, 10542212, 7744820, 26157801, 9346241, 19796012, 10823818, 24755559, 9261139, 8657102, 29050234, 11279241, 8754803, 27701768, 9721103, 10066434, 25504433, 10930537, 26721416, 24992982, 23555990, 24083678, 27098354, 24216290, 22684243, 12189195, 10527519, 9707608, 10196284, 18455150, 16007147, 28629746, 24066302, 8601309, 10421793, 10384135, 10593898, 9346484, 16319058, 16822942, 9792644, 15695387, 9689078, 10398585, 24611898, 15308505, 23110043, 15128824, 12403772, 20191354, 16271147, 15880609, 27682876, 9154800, 17409387, 25881508, 27713151, 9632633, 15843586, 20811049, 7628694, 16015604, 9573057, 11994255, 12138192, 18453612, 12054687, 25412312, 10754328, 18436431, 7878466, 22896603, 10409681, 25695505, 11752211, 7479976, 24558376, 10882136, 22074157, 23468625
S36 Phosphorylation P68400 (CSNK2A1) , Q99558 (MAP3K14) , O15111 (CHUK) , Q9UHD2 (TBK1) , P43250 (GRK6) , Q15418 (RPS6KA1) , Q14164 (IKBKE) , O14920 (IKBKB) , O14965 (AURKA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23675531, 18657515, 15879144, ...10329681, 23118497, 18444250, 18207244, 28597146, 23559010, 7796813, 12377412, 8887633, 16619039, 9346485, 9346484, 8655651, 9789032, 11254493, 8754803, 24957606, 9914500, 24675998, 9244310, 23892407, 10783893, 11408488, 9734360, 15368357, 10490984, 8622650, 15880609, 8660357, 12909638, 10437795, 11815618, 9214631, 25504433, 9252186, 17308110, 28467781, 16818647, 10574930, 10918611, 7744820, 9792644, 26157801, 16271147, 10823818, 24755559, 9261139, 8657102, 9632806, 11279241, 27701768, 9721103, 10066434, 10882136, 26721416, 24992982, 24083678, 27098354, 24216290, 22684243, 10527519, 9707608, 10196284, 18455150, 16007147, 28629746, 8601309, 10421793, 10542212, 16822942, 10754328, 9689078, 10398585, 24611898, 23110043, 15128824, 12403772, 19796012, 9154800, 25881508, 27713151, 9632633, 15843586, 17409387, 7628694, 16015604, 12138192, 12054687, 25412312, 18436431, 7878466, 9346241, 10409681, 10593898, 25695505, 11752211, 7479976, 24558376, 23468625
K38 Ubiquitination PhosphoSitePlus
Y42 Phosphorylation P12931 (SRC) , P06239 (LCK) , P06213 (INSR) , P43405 (SYK) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 17533369, 11408488, 23559010, ...24101387, 9892650, 8797825, 12429743, 11231305, 8940099, 24216290, 10722693, 9792645, 12909638, 26473948, 19074556, 10754328, 12432072
K47 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
T90 Phosphorylation HPRD   PhosphoSitePlus 20068231
K98 Ubiquitination PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T273 Phosphorylation RLIMS-P 9632806
S283 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8657113, 11673497, 8622692
S288 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8622692
T291 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8657113, 11673497, 8622692, ...10398585
S293 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12167702, 10764587, 8622692, ...8668171
T299 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   UniProt 8657113, 11673497
Y305 Phosphorylation P00519 (ABL1) , A0A173G4P4 (Abl fusion) phospho.ELM   PhosphoSitePlus   RLIMS-P 12167702, 12909638, 14757045
Site PTM Type PTM Enzyme Score Source PMID
K21 Ubiquitination PRO 10329681
K22 Ubiquitination PRO 10329681
S32 Phosphorylation PR:000026457 (IkappaB kinase complex (human)) PRO 10329681
S36 Phosphorylation PR:000026457 (IkappaB kinase complex (human)) PRO 10329681


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048597 (hNFKBIA/UbiqLys+) ub PRO
PR:000028546 (hNFKBIA/iso:1/Phos:1) pS32,pS36 PR:000026457 (IkappaB kinase complex (human)) PRO 10329681
PR:000028548 (hNFKBIA/iso:1/PhosUbiq:1) ubK21,ubK22 PRO 10329681
PR:000028548 (hNFKBIA/iso:1/PhosUbiq:1) pS32,pS36 PRO 10329681


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P25963 (NFKBIA) S36 P19838 (NFKB1) unknown eFIP 12377412
Phosphorylation P25963 (NFKBIA) S36 Q96HY6 (DDRGK1) unknown eFIP 23675531
Phosphorylation P25963 (NFKBIA) S36 P19838 (NFKB1) unknown eFIP 15128824