iPTMnet Report for P25116 (F2R)
Protein Information
| UniProt AC / UniProt ID | P25116 / PAR1_HUMAN |
| Protein Name | Proteinase-activated receptor 1 precursor |
| Gene Name | Name: F2R Synonyms:CF2R,PAR1,TR; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P25116 |
| PRO Name | proteinase-activated receptor 1 (human) |
| Definition | A proteinase-activated receptor 1 that is encoded in the genome of human. |
| Short Label | hF2R |
| Category | organism-gene |
DAG ViewP25116 (F2R) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N35 | N-Glycosylation | score3 | GlyGen | 21550978, 24190977 | ||
| K51 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y52 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N62 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
| Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N75 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
| N250 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
| N259 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
| S306 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S375 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
| S376 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
| Y383 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 15023990 | ||
| S384 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
| S391 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| S392 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| S395 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
| S396 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| Y397 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| S399 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| S400 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| S406 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| K407 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T410 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
| S412 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
| S413 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
| S418 | Phosphorylation | score4 | HPRD phospho.ELM PhosphoSitePlus UniProt | 8955127, 23186163 | ||
| Y420 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K421 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K422 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T425 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K51 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| Y52 | H52 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| N62 | D62 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S306 | I306 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S306 | R306 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S375 | F375 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic ] | |
| S376 | F376 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| S392 | F392 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S399 | N399 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S413 | I413 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S413 | G413 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| S418 | N418 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y420 | H420 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| T425 | I425 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |
