Protein Information

Cytoscape View


UniProt AC / UniProt ID P25116 / PAR1_HUMAN
Protein Name Proteinase-activated receptor 1 precursor
Gene Name Name: F2R
Synonyms:CF2R,PAR1,TR;
Organism Homo sapiens (Human)

PRO ID PR:P25116
DAG View
PRO Name proteinase-activated receptor 1 (human)
Definition A proteinase-activated receptor 1 that is encoded in the genome of human.
Short Label hF2R
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25116 (F2R) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N35 N-Glycosylation GlyGen 21550978, 24190977
K51 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
N250 N-Glycosylation GlyGen 21550978
S306 Phosphorylation PhosphoSitePlus
S375 Phosphorylation HPRD   phospho.ELM 8955127
S376 Phosphorylation HPRD   phospho.ELM 8955127
Y383 Phosphorylation phospho.ELM   PhosphoSitePlus 15023990
S384 Phosphorylation HPRD   phospho.ELM 8955127
S391 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
S392 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
S395 Phosphorylation HPRD   phospho.ELM 8955127
S396 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
Y397 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
S399 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
S400 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
S406 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
K407 Ubiquitination PhosphoSitePlus
T410 Phosphorylation HPRD   phospho.ELM 8955127
S412 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 8955127
S413 Phosphorylation HPRD   phospho.ELM 8955127
S418 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 8955127, 23186163
Y420 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
T425 Phosphorylation HPRD   phospho.ELM 8955127


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K51 * Biomuta DOID:263 / kidney cancer [ tcga ]
Y52 H52 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S306 I306 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S306 R306 Biomuta DOID:1612 / breast cancer [ cosmic ]
S376 F376 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
S392 F392 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S399 N399 Biomuta DOID:363 / uterine cancer [ tcga ]
S413 I413 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y420 H420 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T425 I425 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]