iPTMnet Report P25098 GRK2

Protein Information

UniProt AC / UniProt ID	P25098 / ARBK1_HUMAN
Protein Name	Beta-adrenergic receptor kinase 1
Gene Name	Name: GRK2 Synonyms:ADRBK1,BARK,BARK1;
Organism	Homo sapiens (Human)

PRO ID	PR:P25098 DAG View
PRO Name	beta-adrenergic receptor kinase 1 (human)
Definition	A beta-adrenergic receptor kinase 1 that is encoded in the genome of human.
Short Label	hGRK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P25098 (GRK2) as Substrate

P25098

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y13 K19 K21 S29 K30 K31 K45 R50 T54 K57 K62 Y86 Y92 K94 K115 K126 K138 K139 K164 K170 Y206 T213 K215 K220 K230 S247 T248 T263 K319 K344 K345 K346 S350 T353 Y356 S416 S423 C439 K448 Y466 S487 K494 K497 S501 Y506 K545 K557 K628 K644 S670 S676 K677 R683 S685	PTM Type Select all Acetylation Methylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all HPRD IEDB PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
Y13	Phosphorylation	P00533 (EGFR) , P12931 (SRC)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor	18463167, 16725308, 11566877, ...33073183
K19	Ubiquitination		score1	PhosphoSitePlus
K21	Ubiquitination		score1	PhosphoSitePlus
S29	Phosphorylation	P17252 (PRKCA) , P05129 (PRKCG) , Q05655 (PRKCD)	score3	HPRD phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor	11042191
K30	Ubiquitination		score1	PhosphoSitePlus
K31	Ubiquitination		score1	PhosphoSitePlus
K45	Ubiquitination		score1	PhosphoSitePlus
R50	Methylation		score1	PhosphoSitePlus
T54	Phosphorylation		score1	PhosphoSitePlus
K57	Ubiquitination		score1	PhosphoSitePlus
K62	Ubiquitination		score1	PhosphoSitePlus
Y86	Phosphorylation	P12931 (SRC) , P00533 (EGFR)	score4	neXtProt PhosphoSitePlus Signor	18463167, 16725308, 11566877
Y92	Phosphorylation	P12931 (SRC) , P00533 (EGFR)	score4	neXtProt PhosphoSitePlus Signor	18463167, 16725308, 11566877
K94	Ubiquitination		score1	PhosphoSitePlus
K115	Ubiquitination		score1	PhosphoSitePlus
K126	Ubiquitination		score1	PhosphoSitePlus
K138	Ubiquitination		score1	PhosphoSitePlus
K139	Ubiquitination		score1	PhosphoSitePlus
K164	Ubiquitination		score1	PhosphoSitePlus
K170	Ubiquitination		score1	PhosphoSitePlus
Y206	Phosphorylation		score1	PhosphoSitePlus
T213	Phosphorylation		score1	PhosphoSitePlus
K215	Ubiquitination		score1	PhosphoSitePlus
K220	Ubiquitination		score1	PhosphoSitePlus
K230	Ubiquitination		score1	PhosphoSitePlus
S247	Phosphorylation		score1	PhosphoSitePlus
T248	Phosphorylation		score1	PhosphoSitePlus
T263	Phosphorylation		score1	PhosphoSitePlus
K319	Ubiquitination		score1	PhosphoSitePlus
K344	Ubiquitination		score1	PhosphoSitePlus
K345	Ubiquitination		score1	PhosphoSitePlus
K346	Ubiquitination		score1	PhosphoSitePlus
S350	Phosphorylation		score1	PhosphoSitePlus
T353	Phosphorylation		score1	PhosphoSitePlus
Y356	Phosphorylation		score1	PhosphoSitePlus
S416	Phosphorylation		score1	PhosphoSitePlus
S423	Phosphorylation		score1	PhosphoSitePlus
C439	Methylation		score1	IEDB	31844290
K448	Ubiquitination		score1	PhosphoSitePlus
Y466	Phosphorylation		score1	IEDB	32387766
S487	Phosphorylation		score1	PhosphoSitePlus
K494	Ubiquitination		score1	PhosphoSitePlus
K497	Ubiquitination		score1	PhosphoSitePlus
S501	Phosphorylation		score2	IEDB PhosphoSitePlus	32357974
Y506	Phosphorylation		score1	PhosphoSitePlus
K545	Ubiquitination		score1	PhosphoSitePlus
K557	Ubiquitination		score1	PhosphoSitePlus
K628	Ubiquitination		score1	PhosphoSitePlus
K644	Acetylation		score1	PhosphoSitePlus
K644	Ubiquitination		score1	PhosphoSitePlus
S670	Phosphorylation	P27361 (MAPK3) , P24941 (CDK2)	score4	HPRD IEDB neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18088087, 18767875, 10574913, ...22193721, 33936100, 31848261, 19651622, 20080565, 24570070, 10727525, 27720394, 11120772, 33806062, 23186163, 30784271, 32413989, 21081496, 27869121, 23772028
S676	Phosphorylation		score1	PhosphoSitePlus
K677	Ubiquitination		score1	PhosphoSitePlus
R683	Methylation		score1	PhosphoSitePlus
S685	Phosphorylation	P17612 (PRKACA)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P	11278469, 18077607

P25098 (GRK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P05387 (RPLP2) P07550 (ADRB2) P08069 (IGF1R) P08172 (CHRM2) P09497 (CLTB) P15311 (EZR) P18545 (PDE6G) P21731-2 (TBXA2R) P26038 (MSN) P30411 (BDKRB2) P32245 (MC4R) P35241 (RDX) P35367 (HRH1) P35372 (OPRM1) P37840 (SNCA) P41143 (OPRD1) Q14940 (SLC9A5) Q15796 (SMAD2) Q16539 (MAPK14) Q96A54 (ADIPOR1) Q9Y2W7 (KCNIP3)	Site Select all By amino acid All Serine All Threonine By position S7 T24 T53 T62 S95 S102 S105 T123 S129 T197 S205 S232 S234 S239 S250 S251 T271 S282 S283 S286 T287 S288 S290 S294 T302 T307 S309 T310 S311 T312 S329 S330 S355 S356 T356 S357 S358 T358 S363 S366 S373 S375 S377 T384 S396 S398 S401 S407 S411 T558 T564 T567 S702 S709 S711 S712 T714 S1278	Score Select all 1 2 3 4	Source Select all PhosphoSitePlus Signor neXtProt	PMID
P05387 (RPLP2)	S102	score1	Signor	12379128
P05387 (RPLP2)	S105	score1	Signor	12379128
P07550 (ADRB2)	S355	score2	PhosphoSitePlus	14722251
P07550 (ADRB2)	S356	score2	PhosphoSitePlus	14722251
P07550 (ADRB2)	T384	score2	PhosphoSitePlus	8662852
P07550 (ADRB2)	S396	score3	PhosphoSitePlus	8662852, 21868357
P07550 (ADRB2)	S401	score2	PhosphoSitePlus	8662852
P07550 (ADRB2)	S407	score3	PhosphoSitePlus	8662852, 21868357
P07550 (ADRB2)	S411	score2	PhosphoSitePlus	21868357
P08069 (IGF1R)	S1278	score2	PhosphoSitePlus	22509025
P08172 (CHRM2)	S232	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S234	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S250	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S251	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	T271	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S282	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S283	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S286	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	T287	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S288	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S290	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S294	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	T302	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	T307	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S309	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	T310	score2	PhosphoSitePlus	8119296
P08172 (CHRM2)	S311	score2	PhosphoSitePlus	8119296
P09497 (CLTB)	S205	score3	PhosphoSitePlus Signor	22704991
P15311 (EZR)	T567	score4	PhosphoSitePlus Signor	15843435, 19913059
P18545 (PDE6G)	T62	score2	Signor	11502744, 12624098
P21731-2 (TBXA2R)	S239	score2	PhosphoSitePlus	16956790
P21731-2 (TBXA2R)	S357	score2	PhosphoSitePlus	16956790
P26038 (MSN)	T558	score2	PhosphoSitePlus	19913059
P30411 (BDKRB2)	S366	score1	Signor	11517230
P30411 (BDKRB2)	S373	score1	Signor	11517230
P30411 (BDKRB2)	S375	score1	Signor	11517230
P32245 (MC4R)	T312	score1	Signor	12639913
P32245 (MC4R)	S329	score1	Signor	12639913
P32245 (MC4R)	S330	score1	Signor	12639913
P35241 (RDX)	T564	score2	PhosphoSitePlus	19913059
P35367 (HRH1)	S398	score2	PhosphoSitePlus	15107581
P35372 (OPRM1)	T356	score1	Signor	12123746
P35372 (OPRM1)	S357	score1	Signor	12123746
P35372 (OPRM1)	S358	score1	Signor	12123746
P35372 (OPRM1)	S377	score2	PhosphoSitePlus	22375000
P37840 (SNCA)	S129	score3	PhosphoSitePlus Signor	10852916
P41143 (OPRD1)	T358	score1	Signor	11040053
P41143 (OPRD1)	S363	score4	PhosphoSitePlus Signor	18395423, 11040053
Q14940 (SLC9A5)	S702	score2	PhosphoSitePlus	21296876
Q14940 (SLC9A5)	S709	score2	PhosphoSitePlus	21296876
Q14940 (SLC9A5)	S711	score2	PhosphoSitePlus	21296876
Q14940 (SLC9A5)	S712	score2	PhosphoSitePlus	21296876
Q14940 (SLC9A5)	T714	score2	PhosphoSitePlus	21296876
Q15796 (SMAD2)	T197	score2	PhosphoSitePlus	16121194
Q16539 (MAPK14)	T123	score3	neXtProt PhosphoSitePlus Signor	17055984
Q96A54 (ADIPOR1)	S7	score2	PhosphoSitePlus	25696921
Q96A54 (ADIPOR1)	T24	score2	PhosphoSitePlus	25696921
Q96A54 (ADIPOR1)	T53	score2	PhosphoSitePlus	25696921
Q9Y2W7 (KCNIP3)	S95	score2	PhosphoSitePlus	17102134

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000046279 (hGRK2/Phos:2)	Sites Select all pS29	PTM Enzyme	Source Select all PRO	PMID
	PR:000046279 (hGRK2/Phos:2)	pS29		PRO

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P21462 (FPR1) P25098 (GRK2)	Site Select all By amino acid All Serine By position S342 S670	Interactant Select all P25098 (GRK2) Q00987 (MDM2)	Association type Select all inhibited_association unknown	Source Select all eFIP	PMID
	Phosphorylation	P21462 (FPR1)	S342	P25098 (GRK2)	inhibited_association	eFIP	22447027
	Phosphorylation	P25098 (GRK2)	S670	Q00987 (MDM2)	unknown	eFIP	33806062

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K21 K30 K45 R50 T263 K345 Y356 S416 S423 S685	Variant Select all C356 C416 E21 G685 M263 N45 Q50 R30 T345 T685 Y423	Source Select all Biomuta	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K21	E21	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K30	R30	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
K45	N45	Biomuta	DOID:363 / uterine cancer [ icgc ]
R50	Q50	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
T263	M263	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
K345	T345	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y356	C356	Biomuta	DOID:1793 / pancreatic cancer [ icgc ]
S416	C416	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S423	Y423	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
S685	T685	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S685	G685	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P25098 (GRK2)

Protein Information

Interactive Sequence View

P25098 (GRK2) as Substrate

P25098 (GRK2) as PTM Enzyme

Proteoforms

PTM-dependent PPI

PTM sites affected in variants