iPTMnet Report for P25098 (GRK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P25098 / ARBK1_HUMAN
Protein Name Beta-adrenergic receptor kinase 1
Gene Name Name: GRK2
Synonyms:ADRBK1,BARK,BARK1;
Organism Homo sapiens (Human)

PRO ID PR:P25098
DAG View
PRO Name beta-adrenergic receptor kinase 1 (human)
Definition A beta-adrenergic receptor kinase 1 that is encoded in the genome of human.
Short Label hGRK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25098 (GRK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18463167, 16725308, 11566877, ...33073183
Y13 Phosphorylation P00533 (EGFR) neXtProt 18463167
Y13 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16725308, 11566877
K19 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
S29 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 11042191
S29 Phosphorylation P05129 (PRKCG) HPRD   PhosphoSitePlus   Signor 11042191
S29 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   Signor 11042191
S29 Phosphorylation Q05655 (PRKCD) HPRD   Signor 11042191
K30 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
R50 Methylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
Y86 Phosphorylation neXtProt   PhosphoSitePlus   Signor 18463167, 16725308, 11566877
Y86 Phosphorylation P00533 (EGFR) neXtProt 18463167
Y86 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16725308, 11566877
Y92 Phosphorylation neXtProt   PhosphoSitePlus   Signor 18463167, 16725308, 11566877
Y92 Phosphorylation P00533 (EGFR) neXtProt 18463167
Y92 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16725308, 11566877
K94 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
C439 Methylation IEDB 31844290
K448 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation IEDB 32387766
S487 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S501 Phosphorylation IEDB   PhosphoSitePlus 32357974
Y506 Phosphorylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K644 Acetylation PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
S670 Phosphorylation HPRD   IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18088087, 18767875, 10574913, ...22193721, 33936100, 31848261, 19651622, 20080565, 24570070, 10727525, 27720394, 11120772, 33806062, 23186163, 30784271, 32413989, 21081496, 27869121, 23772028
S670 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 20080565
S670 Phosphorylation P27361 (MAPK3) HPRD   neXtProt   Signor 19651622, 18767875, 10574913, ...10727525, 18088087
S676 Phosphorylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
R683 Methylation PhosphoSitePlus
S685 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 11278469, 18077607
S685 Phosphorylation P17612 (PRKACA) HPRD 11278469


P25098 (GRK2) as PTM Enzyme



Substrate Site Score Source PMID
P05387 (RPLP2) S102 Signor 12379128
P05387 (RPLP2) S105 Signor 12379128
P07550 (ADRB2) S355 PhosphoSitePlus 14722251
P07550 (ADRB2) S356 PhosphoSitePlus 14722251
P07550 (ADRB2) T384 PhosphoSitePlus 8662852
P07550 (ADRB2) S396 PhosphoSitePlus 8662852, 21868357
P07550 (ADRB2) S401 PhosphoSitePlus 8662852
P07550 (ADRB2) S407 PhosphoSitePlus 8662852, 21868357
P07550 (ADRB2) S411 PhosphoSitePlus 21868357
P08069 (IGF1R) S1278 PhosphoSitePlus 22509025
P08172 (CHRM2) S232 PhosphoSitePlus 8119296
P08172 (CHRM2) S234 PhosphoSitePlus 8119296
P08172 (CHRM2) S250 PhosphoSitePlus 8119296
P08172 (CHRM2) S251 PhosphoSitePlus 8119296
P08172 (CHRM2) T271 PhosphoSitePlus 8119296
P08172 (CHRM2) S282 PhosphoSitePlus 8119296
P08172 (CHRM2) S283 PhosphoSitePlus 8119296
P08172 (CHRM2) S286 PhosphoSitePlus 8119296
P08172 (CHRM2) T287 PhosphoSitePlus 8119296
P08172 (CHRM2) S288 PhosphoSitePlus 8119296
P08172 (CHRM2) S290 PhosphoSitePlus 8119296
P08172 (CHRM2) S294 PhosphoSitePlus 8119296
P08172 (CHRM2) T302 PhosphoSitePlus 8119296
P08172 (CHRM2) T307 PhosphoSitePlus 8119296
P08172 (CHRM2) S309 PhosphoSitePlus 8119296
P08172 (CHRM2) T310 PhosphoSitePlus 8119296
P08172 (CHRM2) S311 PhosphoSitePlus 8119296
P09497 (CLTB) S205 PhosphoSitePlus   Signor 22704991
P15311 (EZR) T567 PhosphoSitePlus   Signor 15843435, 19913059
P18545 (PDE6G) T62 Signor 11502744, 12624098
P21731-2 (TBXA2R) S239 PhosphoSitePlus 16956790
P21731-2 (TBXA2R) S357 PhosphoSitePlus 16956790
P26038 (MSN) T558 PhosphoSitePlus 19913059
P30411 (BDKRB2) S366 Signor 11517230
P30411 (BDKRB2) S373 Signor 11517230
P30411 (BDKRB2) S375 Signor 11517230
P32245 (MC4R) T312 Signor 12639913
P32245 (MC4R) S329 Signor 12639913
P32245 (MC4R) S330 Signor 12639913
P35241 (RDX) T564 PhosphoSitePlus 19913059
P35367 (HRH1) S398 PhosphoSitePlus 15107581
P35372 (OPRM1) T356 Signor 12123746
P35372 (OPRM1) S357 Signor 12123746
P35372 (OPRM1) S358 Signor 12123746
P35372 (OPRM1) S377 PhosphoSitePlus 22375000
P37840 (SNCA) S129 PhosphoSitePlus   Signor 10852916
P41143 (OPRD1) T358 Signor 11040053
P41143 (OPRD1) S363 PhosphoSitePlus   Signor 18395423, 11040053
Q14940 (SLC9A5) S702 PhosphoSitePlus 21296876
Q14940 (SLC9A5) S709 PhosphoSitePlus 21296876
Q14940 (SLC9A5) S711 PhosphoSitePlus 21296876
Q14940 (SLC9A5) S712 PhosphoSitePlus 21296876
Q14940 (SLC9A5) T714 PhosphoSitePlus 21296876
Q15796 (SMAD2) T197 PhosphoSitePlus 16121194
Q16539 (MAPK14) T123 neXtProt   PhosphoSitePlus   Signor 17055984
Q96A54 (ADIPOR1) S7 PhosphoSitePlus 25696921
Q96A54 (ADIPOR1) T24 PhosphoSitePlus 25696921
Q96A54 (ADIPOR1) T53 PhosphoSitePlus 25696921
Q9Y2W7 (KCNIP3) S95 PhosphoSitePlus 17102134


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046279 (hGRK2/Phos:2) pS29 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P21462 (FPR1) S342 P25098 (GRK2) inhibited_association eFIP 22447027
Phosphorylation P25098 (GRK2) S670 Q00987 (MDM2) unknown eFIP 33806062


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K21 E21 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K30 R30 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K45 N45 Biomuta DOID:363 / uterine cancer [ icgc ]
R50 Q50 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T263 M263 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K345 T345 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y356 C356 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S416 C416 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S423 Y423 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S685 T685 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S685 G685 Biomuta DOID:9256 / colorectal cancer [ cosmic ]