iPTMnet Report for P24666 (ACP1)
Protein Information
| UniProt AC / UniProt ID | P24666 / PPAC_HUMAN |
| Protein Name | Low molecular weight phosphotyrosine protein phosphatase |
| Gene Name | Name: ACP1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P24666 |
| PRO Name | low molecular weight phosphotyrosine protein phosphatase (human) |
| Definition | A low molecular weight phosphotyrosine protein phosphatase that is encoded in the genome of human. |
| Short Label | hACP1 |
| Category | organism-gene |
P24666 (ACP1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score2 | UniProt | 1939112 | ||
| S8 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S20 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K29 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y50 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S62 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R66 | Methylation | score1 | PhosphoSitePlus | |||
| T79 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T85 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y88 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K113 | Sumoylation | score1 | PhosphoSitePlus | |||
| K113 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y120 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K124 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y132 | Phosphorylation | P06239 (LCK) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 10452533, 9038134, 16890200, ... | |
| Y133 | Phosphorylation | P06239 (LCK) | score3 | PhosphoSitePlus UniProt | 9038134 | |
| S137 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T141 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y143 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K156 | Acetylation | score1 | PhosphoSitePlus | |||
| K156 | Ubiquitination | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S20 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T32 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y132 | Phosphorylation | score0 | HPRD | 17016520, 15951569 | ||
| Y133 | Phosphorylation | P06239 (LCK) , P06241 (FYN) | score1 | HPRD | 9038134 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S20 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S62 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K74 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y132 | Phosphorylation | P06239 (LCK) , P06241 (FYN) | score2 | HPRD | 17016520, 9038134 | |
| Y133 | Phosphorylation | P06241 (FYN) , P06239 (LCK) | score1 | HPRD | 9038134 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S8 | Y8 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S20 | L20 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| Y50 | H50 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y120 | C120 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K124 | T124 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| Y132 | C132 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| S137 | C137 | Biomuta | DOID:1540 / parathyroid carcinoma [ cosmic ] | |
| T141 | M141 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] |
DAG View