Protein Information

Cytoscape View

UniProt AC / UniProt ID P24462 / CP3A7_HUMAN
Protein Name Cytochrome P450 3A7
Gene Name Name: CYP3A7
Organism Homo sapiens (Human)

PRO ID PR:P24462
DAG View
PRO Name cytochrome P450 3A7 (human)
Definition A cytochrome P450 3A7 that is encoded in the genome of human.
Short Label hCYP3A7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P24462 (CYP3A7) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y75 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
R158 Methylation PhosphoSitePlus
R161 Methylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
K406 Methylation PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R158 K158 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R158 I158 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R161 K161 Biomuta DOID:1115 / sarcoma [ tcga ]
T286 I286 Biomuta DOID:363 / uterine cancer [ tcga ]
Y432 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y432 C432 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]