iPTMnet Report for P23769 (GATA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23769 / GATA2_HUMAN
Protein Name Endothelial transcription factor GATA-2
Gene Name Name: GATA2
Organism Homo sapiens (Human)

PRO ID PR:P23769
DAG View
PRO Name endothelial transcription factor GATA-2 (human)
Definition An endothelial transcription factor GATA-2 that is encoded in the genome of human.
Short Label hGATA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23769 (GATA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus   UniProt 23186163
R86 Methylation PhosphoSitePlus   UniProt 24129315
S119 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus 25670854
T176 Phosphorylation P06493 (CDK1) PhosphoSitePlus 25670854
S182 O-Glycosylation GlyGen 30379171, 30620550, 35254053
S182 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S192 O-Glycosylation GlyGen 30379171, 30620550, 35254053
S192 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 25056917
S195 O-Glycosylation GlyGen 30620550
S196 O-Glycosylation GlyGen 30379171, 30620550, 35254053
Y213 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
T218 O-Glycosylation GlyGen 30379171, 30620550, 35254053
S220 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
Y314 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
K389 Sumoylation PhosphoSitePlus
S401 Phosphorylation neXtProt   PhosphoSitePlus   Signor 15837948
S401 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 15837948
K409 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation HPRD 20068231
S182 Phosphorylation HPRD 18452278
S401 Phosphorylation HPRD 15837948
S401 Phosphorylation P31749 (AKT1) HPRD 15837948


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P29590-4 (hPML/iso:4) Interaction PR:P23769 (hGATA2) PRO 10938104


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 F71 Biomuta DOID:4159 / skin cancer [ cosmic ]
S119 R119 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T176 M176 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S192 F192 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S195 P195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y213 F213 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S276 F276 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y376 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S401 Y401 Biomuta DOID:4159 / skin cancer [ cosmic ]
K419 E419 Biomuta DOID:9256 / colorectal cancer [ cosmic ]