iPTMnet Report for P23743 (DGKA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23743 / DGKA_HUMAN
Protein Name Diacylglycerol kinase alpha
Gene Name Name: DGKA
Synonyms:DAGK,DAGK1;
Organism Homo sapiens (Human)

PRO ID PR:P23743
DAG View
PRO Name diacylglycerol kinase alpha (human)
Definition A diacylglycerol kinase alpha that is encoded in the genome of human.
Short Label hDGKA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23743 (DGKA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K18 Ubiquitination PhosphoSitePlus
Y22 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S23 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
Y335 Phosphorylation P06239 (LCK) , P12931 (SRC) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 35962191, 17700527, 18424699
S348 Phosphorylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K484 Acetylation PhosphoSitePlus   UniProt 19608861
K484 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
C571 Methylation IEDB 31844290
Y623 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
T670 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y22 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y22 C22 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K26 N26 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K239 N239 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K353 N353 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K384 N384 Biomuta DOID:1319 / brain cancer [ cosmic ]
C571 S571 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ]
Y623 C623 Biomuta DOID:4159 / skin cancer [ cosmic ]
T637 A637 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K643 T643 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S735 C735 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]