iPTMnet Report for P23743 (DGKA)
Protein Information
| UniProt AC / UniProt ID | P23743 / DGKA_HUMAN |
| Protein Name | Diacylglycerol kinase alpha |
| Gene Name | Name: DGKA Synonyms:DAGK,DAGK1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P23743 |
| PRO Name | diacylglycerol kinase alpha (human) |
| Definition | A diacylglycerol kinase alpha that is encoded in the genome of human. |
| Short Label | hDGKA |
| Category | organism-gene |
DAG ViewP23743 (DGKA) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K18 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y22 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| S23 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T24 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K25 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K32 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K41 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y50 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y218 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K239 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K249 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K263 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y335 | Phosphorylation | score4 | IntAct neXtProt PhosphoSitePlus RLIMS-P Signor | 35962191, 17700527, 18424699 | ||
| Y335 | Phosphorylation | P06239 (LCK) | score2 | PhosphoSitePlus | 18424699 | |
| Y335 | Phosphorylation | P12931 (SRC) | score3 | neXtProt PhosphoSitePlus Signor | 17700527 | |
| S348 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K353 | Acetylation | score1 | PhosphoSitePlus | |||
| K353 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K384 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K411 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K422 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K484 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K484 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K487 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S492 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K493 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K543 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K547 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C571 | Methylation | score1 | IEDB | 31844290 | ||
| Y623 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K634 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T637 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K643 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K652 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y669 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T670 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K681 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K691 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K714 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S735 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y22 | C22 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K26 | N26 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K239 | N239 | Biomuta | [ cosmic ] DOID:1115 / sarcoma [ icgc ] | |
| K353 | N353 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| K384 | N384 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| C571 | S571 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ] | |
| Y623 | C623 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T637 | A637 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K643 | T643 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S735 | C735 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |
