iPTMnet Report for P23588 (EIF4B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23588 / IF4B_HUMAN
Protein Name Eukaryotic translation initiation factor 4B
Gene Name Name: EIF4B
Organism Homo sapiens (Human)

PRO ID PR:P23588
DAG View
PRO Name eukaryotic translation initiation factor 4B (human)
Definition A eukaryotic translation initiation factor 4B that is encoded in the genome of human.
Short Label hEIF4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23588 (EIF4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
R70 Methylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S93 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 30784271, 32387766, 20068231
Y96 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T97 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
R117 Methylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
R182 Methylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S192 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340, 20068231
T195 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y211 Phosphorylation PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
K223 Acetylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
R251 Methylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
R261 Methylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
R268 Methylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
R273 Methylation PhosphoSitePlus
R279 Methylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y285 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y291 Phosphorylation PhosphoSitePlus
R292 Methylation PhosphoSitePlus
R297 Methylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
R308 Methylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
K333 Sumoylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
T341 O-Glycosylation GlyGen 31373491
T341 Phosphorylation PhosphoSitePlus
S347 O-Glycosylation GlyGen 31373491
S347 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S350 O-Glycosylation GlyGen 31373491
S350 Phosphorylation PhosphoSitePlus
T351 O-Glycosylation GlyGen 31373491
T351 Phosphorylation PhosphoSitePlus
S352 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S352 Phosphorylation PhosphoSitePlus
S354 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S354 Phosphorylation PhosphoSitePlus
T355 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S359 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S359 Phosphorylation PhosphoSitePlus   UniProt 23186163
K365 Acetylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S406 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...18220336, 17234686, 18836482, 27528663, 35772404, 33658483, 24777602, 25332164, 20068231, 30583073
S406 Phosphorylation Q14680 (MELK) RLIMS-P+ 27528663
S406 Phosphorylation Q9P1W9 (PIM2) neXtProt 17234686
S409 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S409 Phosphorylation PhosphoSitePlus   UniProt 23186163
T412 Phosphorylation PhosphoSitePlus   UniProt 21406692
S418 O-Glycosylation GlyGen 31373491
S418 Phosphorylation PhosphoSitePlus   UniProt 21406692
T420 Phosphorylation PhosphoSitePlus
S422 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30285764, 31106142, 16083285, ...23186163, 36882522, 16763566, 18836482, 22750809, 35772404, 33658483, 15071500, 24275569, 27028868, 20068231
S422 Phosphorylation P23443 (RPS6KB1) neXtProt   PhosphoSitePlus   Signor 16763566, 15071500
S422 Phosphorylation P31749 (AKT1) neXtProt   Signor 18836482
S422 Phosphorylation P51812 (RPS6KA3) neXtProt 16763566
S422 Phosphorylation Q14004 (CDK13) Signor 36882522
S422 Phosphorylation Q15418 (RPS6KA1) neXtProt   PhosphoSitePlus   Signor 16763566, 15071500
S424 O-Glycosylation GlyGen 31373491
S424 Phosphorylation PhosphoSitePlus
S425 O-Glycosylation GlyGen 31373491
S425 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 24275569
T427 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S433 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S433 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
K444 Acetylation PhosphoSitePlus
S445 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 27920218, 21406692, 17081983, ...20068231
T450 Phosphorylation PhosphoSitePlus
S459 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340, 17081983, ...24275569
T461 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
S462 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
K463 Ubiquitination PhosphoSitePlus
K486 Methylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S495 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S495 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
S497 O-Glycosylation GlyGen 31373491
S497 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S498 O-Glycosylation GlyGen 31373491
S498 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 18669648, ...24275569, 20068231
T500 O-Glycosylation GlyGen 31373491
T500 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S504 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S504 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 17081983, ...15302935, 18669648, 24275569, 21635931, 20068231
T506 O-Glycosylation GlyGen 31373491
T506 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
K586 Acetylation PhosphoSitePlus   UniProt 19608861
K586 Ubiquitination PhosphoSitePlus
S588 O-Glycosylation GlyGen 31373491
S589 Phosphorylation PhosphoSitePlus
S591 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34725712, 30059200, 30620550, 34019948, 33465208, 31492838, 31373491, 32119511, 35254053, 34229054
S591 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
S597 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
Y609 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation HPRD 20068231
S16 Phosphorylation HPRD 19413330, 20068231
T18 Phosphorylation HPRD 20068231
T27 Phosphorylation HPRD 20068231
T32 Phosphorylation HPRD 20068231
S35 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 18212344
T75 Phosphorylation HPRD 20068231
S93 Phosphorylation HPRD 19413330, 17322306, 18452278, ...19651622, 18669648, 20068231
Y96 Phosphorylation HPRD 18669648, 18452278
S131 Phosphorylation HPRD 20068231
S155 Phosphorylation HPRD 18452278
S160 Phosphorylation HPRD 18452278
S183 Phosphorylation HPRD 20068231
S192 Phosphorylation HPRD 17287340, 20068231
T195 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 20166139
Y211 Phosphorylation HPRD 17389395
S219 Phosphorylation HPRD 19651622, 18669648, 20068231
S283 Phosphorylation HPRD 18669648, 18212344
Y285 Phosphorylation HPRD 18669648
S311 Phosphorylation HPRD 20068231
S340 Phosphorylation HPRD 18669648, 20068231
S359 Phosphorylation HPRD 18212344, 20068231
T369 Phosphorylation HPRD 20068231
S406 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231
S409 Phosphorylation HPRD 17322306, 19651622
T412 Phosphorylation HPRD 17081983
T420 Phosphorylation HPRD 19651622, 19664995, 20068231
S422 Phosphorylation HPRD 16763566, 19664995, 19651622, ...18707149, 20068231, 17924679
S422 Phosphorylation P23443 (RPS6KB1) HPRD 16763566, 19664995, 19651622, ...18707149, 20068231, 17924679
S425 Phosphorylation HPRD 19651622
S442 Phosphorylation HPRD 20068231
S445 Phosphorylation HPRD 17322306, 18767875, 19664994, ...20068231, 19651622
T450 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 19413330, 17287340, 18767875, ...19651622, 18669648, 20068231
T461 Phosphorylation HPRD 19413330, 18669648, 17287340, ...20068231
S462 Phosphorylation HPRD 19651622, 18669648
S489 Phosphorylation HPRD 20068231
S495 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
S497 Phosphorylation HPRD 19413330, 17081983, 19664995, ...19651622, 18669648, 20166139, 20068231
S498 Phosphorylation HPRD 19413330, 15302935, 19664995, ...19651622, 18669648, 18707149, 20068231
T500 Phosphorylation HPRD 18669648, 20068231
S504 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
S507 Phosphorylation HPRD 17081983
S597 Phosphorylation HPRD 19413330, 19664995, 18669648, ...15345747, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 L52 Biomuta DOID:4159 / skin cancer [ cosmic ]
S93 W93 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R117 L117 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R117 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S131 T131 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R182 H182 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K223 N223 Biomuta DOID:363 / uterine cancer [ icgc ]
Y237 H237 Biomuta [ cosmic ]
R251 Q251 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
R251 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R261 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R273 W273 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R297 S297 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y298 C298 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R308 W308 Biomuta DOID:4159 / skin cancer [ cosmic ]
R308 Q308 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S309 L309 Biomuta DOID:4159 / skin cancer [ cosmic ]
S309 P309 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y316 C316 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S347 P347 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S418 T418 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S425 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T429 N429 Biomuta DOID:4159 / skin cancer [ cosmic ]
S445 Y445 Biomuta DOID:363 / uterine cancer [ icgc ]
S462 C462 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K463 E463 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K463 I463 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T500 P500 Biomuta DOID:2021 / placenta cancer [ cosmic ]
S507 I507 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y593 C593 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S597 Y597 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]