Protein Information

Cytoscape View


UniProt AC / UniProt ID P23588 / IF4B_HUMAN
Protein Name Eukaryotic translation initiation factor 4B
Gene Name Name: EIF4B
Organism Homo sapiens (Human)

PRO ID PR:P23588
DAG View
PRO Name eukaryotic translation initiation factor 4B (human)
Definition A eukaryotic translation initiation factor 4B that is encoded in the genome of human.
Short Label hEIF4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23588 (EIF4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
R70 Methylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S93 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 20068231
Y96 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T97 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
R117 Methylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
R182 Methylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S192 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340, 20068231
T195 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y211 Phosphorylation PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
K223 Ubiquitination PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
R261 Methylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
R268 Methylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
R273 Methylation PhosphoSitePlus
R279 Methylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y285 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y291 Phosphorylation PhosphoSitePlus
R292 Methylation PhosphoSitePlus
R297 Methylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
R308 Methylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
K333 Sumoylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus   UniProt 23186163
K365 Acetylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S406 Phosphorylation Q9P1W9 (PIM2) , Q14680 (MELK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...18220336, 18836482, 27528663, 24777602, 25332164, 20068231, 17234686
S409 Phosphorylation PhosphoSitePlus   UniProt 23186163
T412 Phosphorylation PhosphoSitePlus   UniProt 21406692
S418 Phosphorylation PhosphoSitePlus   UniProt 21406692
T420 Phosphorylation PhosphoSitePlus
S422 Phosphorylation P51812 (RPS6KA3) , Q15418 (RPS6KA1) , P23443 (RPS6KB1) , P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15071500, 23186163, 16763566, ...18836482, 22750809, 16083285, 24275569, 25280966, 27028868, 20068231
S424 Phosphorylation PhosphoSitePlus
S425 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 24275569
T427 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
K444 Acetylation PhosphoSitePlus
S445 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
T450 Phosphorylation PhosphoSitePlus
S459 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340, 17081983, ...24275569
T461 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
S462 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
K463 Ubiquitination PhosphoSitePlus
K486 Methylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S495 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
S497 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S498 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 18669648, ...24275569, 20068231
T500 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S504 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 17081983, ...15302935, 18669648, 24275569, 21635931, 20068231
T506 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
K586 Acetylation PhosphoSitePlus   UniProt 19608861
K586 Ubiquitination PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
S597 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
Y609 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation HPRD 20068231
S16 Phosphorylation HPRD 19413330, 20068231
T18 Phosphorylation HPRD 20068231
T27 Phosphorylation HPRD 20068231
T32 Phosphorylation HPRD 20068231
S35 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 18212344
T75 Phosphorylation HPRD 20068231
S93 Phosphorylation HPRD 19413330, 17322306, 18452278, ...19651622, 18669648, 20068231
Y96 Phosphorylation HPRD 18669648, 18452278
S131 Phosphorylation HPRD 20068231
S155 Phosphorylation HPRD 18452278
S160 Phosphorylation HPRD 18452278
S183 Phosphorylation HPRD 20068231
S192 Phosphorylation HPRD 17287340, 20068231
T195 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 20166139
Y211 Phosphorylation HPRD 17389395
S219 Phosphorylation HPRD 19651622, 18669648, 20068231
S283 Phosphorylation HPRD 18669648, 18212344
Y285 Phosphorylation HPRD 18669648
S311 Phosphorylation HPRD 20068231
S340 Phosphorylation HPRD 18669648, 20068231
S359 Phosphorylation HPRD 18212344, 20068231
T369 Phosphorylation HPRD 20068231
S406 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231
S409 Phosphorylation HPRD 17322306, 19651622
T412 Phosphorylation HPRD 17081983
T420 Phosphorylation HPRD 19651622, 19664995, 20068231
S422 Phosphorylation P23443 (RPS6KB1) HPRD 16763566, 19664995, 19651622, ...18707149, 20068231, 17924679
S425 Phosphorylation HPRD 19651622
S442 Phosphorylation HPRD 20068231
S445 Phosphorylation HPRD 17322306, 18767875, 19664994, ...20068231, 19651622
T450 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 19413330, 17287340, 18767875, ...19651622, 18669648, 20068231
T461 Phosphorylation HPRD 19413330, 18669648, 17287340, ...20068231
S462 Phosphorylation HPRD 19651622, 18669648
S489 Phosphorylation HPRD 20068231
S495 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
S497 Phosphorylation HPRD 19413330, 17081983, 19664995, ...19651622, 18669648, 20166139, 20068231
S498 Phosphorylation HPRD 19413330, 15302935, 19664995, ...19651622, 18669648, 18707149, 20068231
T500 Phosphorylation HPRD 18669648, 20068231
S504 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
S507 Phosphorylation HPRD 17081983
S597 Phosphorylation HPRD 19413330, 19664995, 18669648, ...15345747, 19415658, 20068231