iPTMnet Report for P22681 (CBL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22681 / CBL_HUMAN
Protein Name E3 ubiquitin-protein ligase CBL
Gene Name Name: CBL
Synonyms:CBL2,RNF55;
Organism Homo sapiens (Human)

PRO ID PR:P22681
DAG View
PRO Name E3 ubiquitin-protein ligase CBL (human)
Definition An E3 ubiquitin-protein ligase CBL that is encoded in the genome of human.
Short Label hCBL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22681 (CBL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   RLIMS-P 23845085
S17 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
C59 Methylation IEDB 31844290
K74 Ubiquitination PhosphoSitePlus
T91 Phosphorylation IEDB 32357974
K105 Ubiquitination PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T245 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
T317 Phosphorylation IEDB 35494241
Y337 Phosphorylation IntAct   phospho.ELM 10608804, 8524328
Y368 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 15117950
Y371 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 31120930, 22266821, 29053960, ...10635327, 11997497, 24469048
Y371 Phosphorylation P00533 (EGFR) neXtProt 10635327
Y371 Phosphorylation P06213 (INSR) HPRD   phospho.ELM 11997497, 10635327
Y371 Phosphorylation P07948 (LYN) PhosphoSitePlus 24469048
C372 Methylation IEDB 31844290
K424 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus   UniProt 23186163
S441 Phosphorylation PhosphoSitePlus
S452 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Y455 Phosphorylation HPRD   PhosphoSitePlus 17389395
S483 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20058876, 23186163
S486 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S512 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
S512 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
Y552 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15951569, 17389395
T568 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
S589 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
S589 Phosphorylation PhosphoSitePlus
S601 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 30379171, 32574038, 32938750, 34019948, 28657654, 30059200, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
S601 Phosphorylation PhosphoSitePlus
S604 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
S605 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
S606 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
T610 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
S619 Phosphorylation HPRD   PhosphoSitePlus   Signor 11024037
S619 Phosphorylation P17252 (PRKCA) HPRD   Signor 11024037
S623 O-Glycosylation GlyGen 31373491
S623 Phosphorylation HPRD   PhosphoSitePlus   Signor 11024037
S623 Phosphorylation P17252 (PRKCA) HPRD   Signor 11024037
S626 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 34019948, 28657654, 35254053, 28580691, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092, 30059200
S639 Phosphorylation HPRD   PhosphoSitePlus   Signor 11024037
S639 Phosphorylation P17252 (PRKCA) HPRD   Signor 11024037
T640 Phosphorylation PhosphoSitePlus
S642 Phosphorylation HPRD   PhosphoSitePlus   Signor 11024037
S642 Phosphorylation P17252 (PRKCA) HPRD   Signor 11024037
T645 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S667 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16094384
S668 Phosphorylation PhosphoSitePlus
S669 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 12522270, 23186163, 15144186
Y674 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 20622007, 15144186, ...11687594, 15592455, 12522270, 15922744, 16497976
S675 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16094384
T698 Phosphorylation PhosphoSitePlus
Y700 Phosphorylation HPRD   IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 12881521, 8524328, 9200440, ...23352614, 15556646, 20622007, 23845085, 9525940, 9535867, 20940296, 17389395, 10829062, 11239464, 22880054, 11994282, 12522270, 9102067, 11997497, 15922744, 16497976
Y700 Phosphorylation P00519 (ABL1) neXtProt 15556646
Y700 Phosphorylation P00533 (EGFR) HPRD 11994282, 17389395, 11239464, ...15556646, 16497976
Y700 Phosphorylation P06213 (INSR) phospho.ELM 11997497
Y700 Phosphorylation P06239 (LCK) PhosphoSitePlus 9525940
Y700 Phosphorylation P06241 (FYN) phospho.ELM   PhosphoSitePlus 9525940
Y700 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus 9535867, 9525940
T702 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
T713 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
Y731 Phosphorylation HPRD   IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10799548, 15556646, 9160881, ...9414268, 9890970, 15922744, 9535867, 15581361, 12604776, 10934191, 23352614, 14615606, 10092522, 23874206, 33627783, 30181811, 14739300, 25301722, 27050377, 11239464, 11994282, 9525940
Y731 Phosphorylation P00533 (EGFR) HPRD 11994282, 10092522, 9890970, ...11239464, 10799548
Y731 Phosphorylation P06239 (LCK) PhosphoSitePlus 9525940
Y731 Phosphorylation P06241 (FYN) HPRD   phospho.ELM   PhosphoSitePlus   Signor 10799548, 15556646, 10092522, ...9890970, 11239464, 11994282, 9525940
Y731 Phosphorylation P08631 (HCK) HPRD 11994282, 10092522, 9890970, ...11239464, 10799548
Y731 Phosphorylation P12931 (SRC) PhosphoSitePlus 11994282, 14739300, 12604776
Y731 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus 9535867, 9525940
Y735 Phosphorylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
Y774 Phosphorylation HPRD   IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 9535867, 23606532, 8524328, ...15556646, 23352614, 14615606, 11997497, 20622007, 34062268, 11994282, 27050377, 24457597, 10829062, 11239464, 12604776, 8626543, 12522270, 26848865, 9525940, 15922744
Y774 Phosphorylation P00533 (EGFR) HPRD 11994282, 11239464, 15556646
Y774 Phosphorylation P06239 (LCK) PhosphoSitePlus 9525940
Y774 Phosphorylation P06241 (FYN) phospho.ELM   PhosphoSitePlus 9525940
Y774 Phosphorylation P12931 (SRC) PhosphoSitePlus 12604776
Y774 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus 9535867, 9525940
T789 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S900 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y371 Phosphorylation PRO 15117950, 11997497


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046577 (hCBL/Phos:2) pY700,pY731,pY774 PRO
PR:000026223 (hCBL/iso:1/Phos:1) pY371 PRO 11997497, 15117950


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) S1071 P22681 (CBL) increased_association eFIP 20877636
Phosphorylation P22681 (CBL) Y774 P46108 (CRK) unknown eFIP 34062268
Phosphorylation P22681 (CBL) Y700 P15498 (VAV1) unknown eFIP 12881521
Phosphorylation P22681 (CBL) Y731 Q96B97 (SH3KBP1) inhibited_association eFIP 33627783
Phosphorylation P22681 (CBL) Y371 P62837 (UBE2D2) unknown eFIP 31120930
Phosphorylation P43405 (SYK) Y323 P22681 (CBL) unknown eFIP 27614019


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K7 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
C59 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y141 C141 Biomuta [ cosmic ]
T245 I245 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y337 C337 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y368 N368 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y368 C368 Biomuta [ cosmic ]
Y371 S371 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y371 D371 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y371 C371 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y371 N371 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y371 H371 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S441 C441 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S486 F486 Biomuta DOID:1324 / lung cancer [ cosmic ]
S605 F605 Biomuta DOID:4159 / skin cancer [ cosmic ]
S669 Y669 Biomuta DOID:363 / uterine cancer [ icgc ]
S675 C675 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S675 F675 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y700 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S704 C704 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S705 C705 Biomuta DOID:1324 / lung cancer [ cosmic ]
S714 F714 Biomuta DOID:4159 / skin cancer [ cosmic ]
S716 G716 Biomuta DOID:2998 / testicular cancer [ cosmic ]
S717 L717 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S717 P717 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y731 C731 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y731 H731 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T762 S762 Biomuta DOID:1324 / lung cancer [ cosmic ]
S794 Y794 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S799 F799 Biomuta DOID:4159 / skin cancer [ cosmic ]
S866 N866 Biomuta DOID:4159 / skin cancer [ cosmic ]