Protein Information

Cytoscape View


UniProt AC / UniProt ID P22681 / CBL_HUMAN
Protein Name E3 ubiquitin-protein ligase CBL
Gene Name Name: CBL
Synonyms:CBL2,RNF55;
Organism Homo sapiens (Human)

PRO ID PR:P22681
DAG View
PRO Name E3 ubiquitin-protein ligase CBL (human)
Definition An E3 ubiquitin-protein ligase CBL that is encoded in the genome of human.
Short Label hCBL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22681 (CBL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   RLIMS-P 23845085
S17 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
Y337 Phosphorylation phospho.ELM 10608804
Y368 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 15117950
Y371 Phosphorylation P06213 (INSR) , P07948 (LYN) , P00533 (EGFR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 31120930, 22266821, 29053960, ...10635327, 11997497, 24469048
K424 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus   UniProt 23186163
S441 Phosphorylation PhosphoSitePlus
S452 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Y455 Phosphorylation HPRD   PhosphoSitePlus 17389395
S483 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20058876, 23186163
S486 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
Y552 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15951569, 17389395
T568 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
S619 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   Signor 11024037
S623 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   Signor 11024037
S639 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   Signor 11024037
T640 Phosphorylation PhosphoSitePlus
S642 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   Signor 11024037
T645 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S667 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16094384
S668 Phosphorylation PhosphoSitePlus
S669 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 12522270, 23186163, 15144186
Y674 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 20622007, 15144186, ...11687594, 15592455, 12522270, 15922744, 16497976
S675 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16094384
T698 Phosphorylation PhosphoSitePlus
Y700 Phosphorylation P43405 (SYK) , P06241 (FYN) , P00533 (EGFR) , P00519 (ABL1) , P06239 (LCK) , P06213 (INSR) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 12881521, 17389395, 15556646, ...23352614, 23845085, 20622007, 11997497, 9535867, 20940296, 10829062, 11239464, 22880054, 11994282, 12522270, 9102067, 9525940, 15922744, 16497976
T702 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
T713 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
Y731 Phosphorylation P12931 (SRC) , P08631 (HCK) , P43405 (SYK) , P06239 (LCK) , P00533 (EGFR) , P06241 (FYN) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14739300, 10092522, 11239464, ...23352614, 14615606, 11994282, 25301722, 9535867, 27050377, 9890970, 10799548, 15581361, 12604776, 10934191, 23874206, 9525940, 15922744, 15556646
Y735 Phosphorylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
Y774 Phosphorylation P00533 (EGFR) , P06241 (FYN) , P12931 (SRC) , P06239 (LCK) , P43405 (SYK) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 23606532, 15556646, 23352614, ...14615606, 20622007, 11997497, 9535867, 27050377, 24457597, 10829062, 11239464, 12604776, 11994282, 12522270, 26848865, 9525940, 15922744
T789 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
S900 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y371 Phosphorylation PRO 15117950, 11997497


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046577 (hCBL/Phos:2) pY700,pY731,pY774 PRO
PR:000026223 (hCBL/iso:1/Phos:1) pY371 PRO 11997497, 15117950


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) S1071 P22681 (CBL) increased_association eFIP 20877636
Phosphorylation P22681 (CBL) Y371 P62837 (UBE2D2) unknown eFIP 31120930
Phosphorylation P22681 (CBL) Y700 P15498 (VAV1) unknown eFIP 12881521
Phosphorylation P43405 (SYK) Y323 P22681 (CBL) unknown eFIP 27614019