iPTMnet Report for P22216 (RAD53)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22216 / RAD53_YEAST
Protein Name Serine/threonine-protein kinase RAD53
Gene Name Name: RAD53
Synonyms:MEC2,SAD1,SPK1;OrderedLocusNames:YPL153C;ORFNames:P2588;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

PRO ID PR:P22216
DAG View
PRO Name serine/threonine-protein kinase RAD53 (yeast)
Definition A protein that is a translation product of the RAD53 gene in yeast.
Short Label yRAD53
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22216 (RAD53) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation SGD 24302356, 33481703
T8 Phosphorylation SGD 24302356, 33481703
S11 Phosphorylation SGD 24302356, 33491328
T12 Phosphorylation SGD 24302356
T15 Phosphorylation SGD 24302356
S24 Phosphorylation BioGRID   SGD   UniProt 15972895, 24302356, 33491328, ...18407956
S49 Phosphorylation BioGRID 15972895
S53 Phosphorylation SGD 24302356, 33491328
S82 Phosphorylation SGD 24302356
S165 Phosphorylation BioGRID   SGD 16085488, 24302356, 17287358
T170 Phosphorylation BioGRID   SGD 16085488, 24302356, 20489023
S171 Phosphorylation BioGRID   SGD 16085488, 20489023
S175 Phosphorylation BioGRID   SGD   UniProt 24302356, 33481703, 32597660, ...18407956, 33491328, 21126336, 23749301, 15972895
T179 Phosphorylation SGD 24302356
S180 Phosphorylation SGD 24302356
S181 Phosphorylation BioGRID   SGD 24302356, 18407956
T182 Phosphorylation SGD 24302356, 18407956
S184 Phosphorylation BioGRID   SGD 16085488, 24302356
S185 Phosphorylation BioGRID   SGD 16085488, 24302356, 18407956
S198 Phosphorylation BioGRID   SGD 16085488, 24302356, 33491328
S350 Phosphorylation BioGRID   RLIMS-P   SGD 16085488, 24302356, 33491328, ...15972895, 18407956
T354 Phosphorylation BioGRID   RLIMS-P   SGD 24302356, 20489023, 18407956, ...16085488, 33491328, 17114794
T358 Phosphorylation SGD 24302356
S373 Phosphorylation BioGRID   SGD 16085488, 24302356, 33481703, ...15972895, 33491328
S375 Phosphorylation BioGRID   SGD 24302356, 33481703, 20489023, ...18407956, 16085488, 33491328, 15972895
S411 Phosphorylation BioGRID   SGD 16085488, 33491328
S424 Phosphorylation BioGRID   SGD 15972895, 24302356, 33491328, ...17563356, 17287358
S473 Phosphorylation SGD 24302356, 33491328
S475 Phosphorylation SGD 33491328
S480 Phosphorylation SGD 24302356, 33491328
S485 Phosphorylation BioGRID   SGD 16085488, 24302356, 20190278, ...33491328
S485 Phosphorylation P38110 (TEL1) BioGRID 16085488, 20190278
S485 Phosphorylation P38111 (MEC1) BioGRID 16085488, 20190278
S489 Phosphorylation BioGRID   SGD 16085488, 24302356, 20190278, ...15972895, 33491328
S489 Phosphorylation P38110 (TEL1) BioGRID 16085488, 20190278, 15972895
S489 Phosphorylation P38111 (MEC1) BioGRID 16085488, 20190278, 15972895
T543 Phosphorylation BioGRID   SGD 16085488, 24302356, 33491328, ...15972895
S547 Phosphorylation BioGRID   SGD   UniProt 24302356, 18407956, 33491328, ...16085488, 23749301, 15972895
T552 Phosphorylation SGD 24302356
S560 Phosphorylation BioGRID   SGD   UniProt 24302356, 17563356, 20489023, ...18407956, 23749301, 16085488, 33491328, 15972895
T563 Phosphorylation BioGRID   SGD 16085488, 24302356, 33491328, ...18407956
S568 Phosphorylation BioGRID   SGD 16085488, 24302356, 33491328
S569 Phosphorylation BioGRID   SGD 16085488, 24302356, 33491328
S586 Phosphorylation SGD 24302356
S591 Phosphorylation SGD 33491328
S635 Phosphorylation BioGRID   SGD 24302356, 20489023
S639 Phosphorylation SGD 24302356
T731 Phosphorylation BioGRID   SGD 19779198, 24302356
S743 Phosphorylation SGD 24302356
S745 Phosphorylation BioGRID   SGD 16085488, 24302356, 23749301
S746 Phosphorylation BioGRID   SGD 16085488, 24302356
S747 Phosphorylation BioGRID   SGD 19779198, 24302356
S748 Phosphorylation BioGRID   SGD 24302356, 20489023, 18407956, ...16085488, 23749301, 15972895
S750 Phosphorylation BioGRID   SGD 16085488, 24302356, 33481703, ...33491328, 23749301
S757 Phosphorylation SGD 24302356
T759 Phosphorylation SGD 24302356
S766 Phosphorylation SGD 24302356, 23749301, 33491328
S774 Phosphorylation BioGRID   RLIMS-P   SGD   UniProt 24302356, 17563356, 20046099, ...20489023, 18407956, 23749301, 19779198, 19801655, 33491328, 15972895
S774 Phosphorylation P00546 (CDC28) BioGRID 19801655, 15972895, 20489023, ...17563356, 18407956
S774 Phosphorylation P24869 (CLB2) BioGRID 19801655, 15972895, 20489023, ...17563356, 18407956
S789 Phosphorylation BioGRID   RLIMS-P   SGD 24302356, 33481703, 17563356, ...20046099, 20489023, 18407956, 23749301, 16085488, 33491328, 15972895
S791 Phosphorylation BioGRID   RLIMS-P   SGD 24302356, 17563356, 20046099, ...18407956, 16085488, 33491328
S793 Phosphorylation BioGRID   SGD   UniProt 24302356, 33481703, 17563356, ...20489023, 18407956, 33491328, 16085488, 23749301, 15972895
S795 Phosphorylation BioGRID   SGD 16085488, 24302356, 33481703, ...18407956
T811 Phosphorylation SGD 22323608
S812 Phosphorylation SGD 24302356, 22323608, 33491328, ...18407956
S821 Phosphorylation SGD 22323608


P22216 (RAD53) as PTM Enzyme



Substrate Site Score Source PMID
P39705 (NUP60) S382 BioGRID 17563356, 15665377, 20702584, ...18407956, 17287358, 19779198, 21177495


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46946 (SAE2) T90 P22216 (RAD53) unknown eFIP 25762720