iPTMnet Report for P21953 (BCKDHB)
Protein Information
| UniProt AC / UniProt ID | P21953 / ODBB_HUMAN |
| Protein Name | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor |
| Gene Name | Name: BCKDHB |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P21953 |
| PRO Name | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (human) |
| Definition | A 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial that is encoded in the genome of human. |
| Short Label | hBCKDHB |
| Category | organism-gene |
DAG ViewP21953 (BCKDHB) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y195 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C207 | Methylation | score1 | IEDB | 31844290 | ||
| K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K241 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K294 | Acetylation | score1 | PhosphoSitePlus | |||
| K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C299 | Methylation | score1 | IEDB | 31844290 | ||
| S318 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S328 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y363 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y383 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y392 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y195 | C195 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| C207 | Y207 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K232 | E232 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| K232 | T232 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y383 | C383 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |
