Protein Information

Cytoscape View


UniProt AC / UniProt ID P21953 / ODBB_HUMAN
Protein Name 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor
Gene Name Name: BCKDHB
Organism Homo sapiens (Human)

PRO ID PR:P21953
DAG View
PRO Name 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (human)
Definition A 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial that is encoded in the genome of human.
Short Label hBCKDHB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21953 (BCKDHB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y195 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K241 Acetylation PhosphoSitePlus   UniProt 19608861
K294 Acetylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y195 C195 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K232 E232 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K232 T232 Biomuta DOID:363 / uterine cancer [ tcga ]
K294 N294 Biomuta DOID:3571 / liver cancer [ icgc ]