iPTMnet Report for P21953 (BCKDHB)
Protein Information
UniProt AC / UniProt ID | P21953 / ODBB_HUMAN |
Protein Name | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor |
Gene Name | Name: BCKDHB |
Organism | Homo sapiens (Human) |
PRO ID | PR:P21953 |
PRO Name | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (human) |
Definition | A 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial that is encoded in the genome of human. |
Short Label | hBCKDHB |
Category | organism-gene |
P21953 (BCKDHB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y195 | Phosphorylation | score1 | PhosphoSitePlus | |||
C207 | Methylation | score1 | IEDB | 31844290 | ||
K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
K241 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K294 | Acetylation | score1 | PhosphoSitePlus | |||
K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
C299 | Methylation | score1 | IEDB | 31844290 | ||
S318 | Phosphorylation | score1 | PhosphoSitePlus | |||
S328 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y363 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y383 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y392 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y195 | C195 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
C207 | Y207 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K232 | E232 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
K232 | T232 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
Y383 | C383 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |