iPTMnet Report for P21860 (ERBB3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21860 / ERBB3_HUMAN
Protein Name Receptor tyrosine-protein kinase erbB-3 precursor
Gene Name Name: ERBB3
Synonyms:HER3;
Organism Homo sapiens (Human)

PRO ID PR:P21860
DAG View
PRO Name receptor tyrosine-protein kinase erbB-3 (human)
Definition A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of human.
Short Label hERBB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21860 (ERBB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
N250 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977, ...29741879
N353 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977, ...29741879
N408 N-Glycosylation GlyGen   UniProt 12154198
N414 N-Glycosylation GlyGen   UniProt 12154198
N437 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977, ...29741879
N469 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977
N522 N-Glycosylation GlyGen   UniProt 12154198
N566 N-Glycosylation GlyGen   UniProt 12154198
N616 N-Glycosylation GlyGen 23090970, 24190977
T640 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S693 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
K736 Methylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
Y868 Phosphorylation IntAct   PhosphoSitePlus 16273093
S869 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus   UniProt 24275569
T996 Phosphorylation PhosphoSitePlus
S1052 Phosphorylation PhosphoSitePlus
Y1054 Phosphorylation IntAct   PhosphoSitePlus 16729043, 16273093
S1083 Phosphorylation PhosphoSitePlus
S1094 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
Y1132 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation PhosphoSitePlus
S1147 Phosphorylation PhosphoSitePlus
Y1159 Phosphorylation PhosphoSitePlus
T1164 Phosphorylation PhosphoSitePlus
Y1197 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P 24044505, 28114269, 16729043, ...16273093, 27514687, 26735176
Y1199 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 9516479, 16729043
S1207 Phosphorylation PhosphoSitePlus
S1215 Phosphorylation PhosphoSitePlus
Y1222 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P 16729043, 16273093, 28114269
Y1224 Phosphorylation IntAct 16273093
Y1260 Phosphorylation IntAct   PhosphoSitePlus 16729043, 16273093
Y1262 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 16729043, 9516479, 16273093
Y1276 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   Signor 7929151, 16729043, 11546794, ...16273093
Y1276 Phosphorylation P00533 (EGFR) Signor 7929151
S1285 Phosphorylation PhosphoSitePlus
Y1289 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26208478, 23866081, 33888713, ...26942872, 11546794, 29712619, 26934000, 18682844, 16729043, 28114269, 23342251, 32815546, 18700973, 26095475, 16273093, 27531070, 25849870, 27514687, 27768588, 7929151, 26148232
Y1289 Phosphorylation P00533 (EGFR) Signor 7929151
Y1307 Phosphorylation PhosphoSitePlus   RLIMS-P+ 28114269
Y1307 Phosphorylation Q01973 (ROR1) RLIMS-P+ 28114269
R1309 Phosphorylation IntAct 16273093
T1312 Phosphorylation PhosphoSitePlus
S1315 Phosphorylation PhosphoSitePlus
T1319 Phosphorylation PhosphoSitePlus
Y1328 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 16729043, 25367220, 9694850, ...28114269
S1331 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S686 Phosphorylation HPRD 18691976
T873 Phosphorylation HPRD 12824184
T873 Phosphorylation Q00535 (CDK5) HPRD 12824184
Y1054 Phosphorylation HPRD 16729043
S1123 Phosphorylation HPRD 12824184
S1123 Phosphorylation Q00535 (CDK5) HPRD 12824184
Y1197 Phosphorylation HPRD 16729043
Y1199 Phosphorylation HPRD 16729043, 9516479
Y1222 Phosphorylation HPRD 16729043
Y1260 Phosphorylation HPRD 16729043
Y1262 Phosphorylation HPRD 16729043, 9516479
Y1276 Phosphorylation HPRD 16729043, 11546794
Y1289 Phosphorylation HPRD 16729043, 11546794
Y1328 Phosphorylation HPRD 16729043, 17389395, 9694850
Site PTM Type PTM Enzyme Score Source PMID
T169 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T169 A169 Biomuta DOID:3571 / liver cancer [ cosmic ]
S174 F174 Biomuta DOID:4159 / skin cancer [ cosmic ]
N414 Y414 Biomuta DOID:1324 / lung cancer [ cosmic ]
N414 K414 Biomuta DOID:263 / kidney cancer [ cosmic ]
N469 K469 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
N522 Y522 Biomuta DOID:4159 / skin cancer [ cosmic ]
N616 K616 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T640 I640 Biomuta DOID:4159 / skin cancer [ cosmic ]
K736 N736 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S846 I846 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S982 C982 Biomuta DOID:1324 / lung cancer [ cosmic ]
S982 R982 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1052 C1052 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1104 F1104 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1134 F1134 Biomuta [ cosmic ]
S1147 F1147 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y1159 F1159 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1164 A1164 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1199 C1199 Biomuta DOID:363 / uterine cancer [ icgc ]
R1309 H1309 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1309 C1309 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1315 N1315 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]