Protein Information

Cytoscape View


UniProt AC / UniProt ID P21860 / ERBB3_HUMAN
Protein Name Receptor tyrosine-protein kinase erbB-3 precursor
Gene Name Name: ERBB3
Synonyms:HER3;
Organism Homo sapiens (Human)

PRO ID PR:P21860
DAG View
PRO Name receptor tyrosine-protein kinase erbB-3 (human)
Definition A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of human.
Short Label hERBB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21860 (ERBB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
N250 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977, ...29741879
N353 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977, ...29741879
N408 N-Glycosylation GlyGen   UniProt 12154198
N414 N-Glycosylation GlyGen   UniProt 12154198
N437 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977, ...29741879
N469 N-Glycosylation GlyGen   UniProt 23090970, 12154198, 24190977
N522 N-Glycosylation GlyGen   UniProt 12154198
N566 N-Glycosylation GlyGen   UniProt 12154198
N616 N-Glycosylation GlyGen 23090970, 24190977
T640 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S693 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
K736 Methylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
Y868 Phosphorylation IntAct   PhosphoSitePlus 16273093
S869 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus   UniProt 24275569
T996 Phosphorylation PhosphoSitePlus
S1052 Phosphorylation PhosphoSitePlus
Y1054 Phosphorylation IntAct   PhosphoSitePlus 16729043, 16273093
S1083 Phosphorylation PhosphoSitePlus
S1094 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
Y1132 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation PhosphoSitePlus
S1147 Phosphorylation PhosphoSitePlus
Y1159 Phosphorylation PhosphoSitePlus
T1164 Phosphorylation PhosphoSitePlus
Y1197 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P 24044505, 28114269, 16729043, ...16273093, 27514687, 26735176
Y1199 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 9516479, 16729043
S1207 Phosphorylation PhosphoSitePlus
S1215 Phosphorylation PhosphoSitePlus
Y1222 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P 16729043, 16273093, 28114269
Y1224 Phosphorylation IntAct 16273093
Y1260 Phosphorylation IntAct   PhosphoSitePlus 16729043, 16273093
Y1262 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 16729043, 9516479, 16273093
Y1276 Phosphorylation P00533 (EGFR) IntAct   phospho.ELM   PhosphoSitePlus   Signor 7929151, 16729043, 11546794, ...16273093
S1285 Phosphorylation PhosphoSitePlus
Y1289 Phosphorylation P00533 (EGFR) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 33888713, 26942872, 11546794, ...28114269, 27531070, 26095475, 26208478, 26934000, 18682844, 25849870, 23342251, 29712619, 23866081, 26148232, 32815546, 27768588, 7929151, 16729043, 16273093, 27514687
Y1307 Phosphorylation Q01973 (ROR1) PhosphoSitePlus   RLIMS-P+ 28114269
R1309 Phosphorylation IntAct 16273093
T1312 Phosphorylation PhosphoSitePlus
S1315 Phosphorylation PhosphoSitePlus
T1319 Phosphorylation PhosphoSitePlus
Y1328 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 16729043, 25367220, 9694850, ...28114269
S1331 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S686 Phosphorylation HPRD 18691976
T873 Phosphorylation Q00535 (CDK5) HPRD 12824184
Y1054 Phosphorylation HPRD 16729043
S1123 Phosphorylation Q00535 (CDK5) HPRD 12824184
Y1197 Phosphorylation HPRD 16729043
Y1199 Phosphorylation HPRD 16729043, 9516479
Y1222 Phosphorylation HPRD 16729043
Y1260 Phosphorylation HPRD 16729043
Y1262 Phosphorylation HPRD 16729043, 9516479
Y1276 Phosphorylation HPRD 16729043, 11546794
Y1289 Phosphorylation HPRD 16729043, 11546794
Y1328 Phosphorylation HPRD 16729043, 17389395, 9694850
Site PTM Type PTM Enzyme Score Source PMID
T169 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P21860 (ERBB3) Y1289 P11362 (FGFR1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1224 Q92569 (PIK3R3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 Q9UQQ2 (SH2B3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 Q8IZW8 (TNS4) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 Q08881 (ITK) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 P16591 (FER) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 Q9UN19 (DAPP1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 P00519 (ABL1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1222 O00459 (PIK3R2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1222 P27986 (PIK3R1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1222 O00459 (PIK3R2) unknown eFIP 16729043
Phosphorylation P21860 (ERBB3) Y1262 Q14451 (GRB7) unknown eFIP 9516479
Phosphorylation P21860 (ERBB3) Y1262 P62993 (GRB2) unknown eFIP 16729043
Phosphorylation P21860 (ERBB3) Y1328 P29353 (SHC1) unknown eFIP 16729043
Phosphorylation P21860 (ERBB3) Y1197 O75553 (DAB1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1197 Q63HR2 (TNS2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1197 Q14451 (GRB7) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y868 P43405 (SYK) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y868 O75815 (BCAR3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y868 P20936 (RASA1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 Q13882 (PTK6) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P42681 (TXK) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 Q68CZ2 (TNS3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 O43639 (NCK2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P08631 (HCK) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P52757 (CHN2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P46109 (CRKL) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P12931 (SRC) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P19174 (PLCG1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P29353 (SHC1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 Q9UKW4 (VAV3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P46108 (CRK) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P43403 (ZAP70) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P16333 (NCK1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 O60674 (JAK2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P52333 (JAK3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 Q92529 (SHC3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 P52735 (VAV2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1276 Q13671 (RIN1) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1199 P41240 (CSK) unknown eFIP 16729043
Phosphorylation P21860 (ERBB3) Y1224 P42684 (ABL2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1289 P04626 (ERBB2) unknown eFIP 23866081


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N469 S469 Biomuta DOID:363 / uterine cancer [ tcga ]
S846 I846 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:5041 / esophageal cancer [ tcga ]
S982 C982 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1147 F1147 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y1199 C1199 Biomuta DOID:363 / uterine cancer [ tcga ]
S1315 N1315 Biomuta DOID:9256 / colorectal cancer [ tcga ]