iPTMnet Report for P20273 (CD22)
Protein Information
| UniProt AC / UniProt ID | P20273 / CD22_HUMAN |
| Protein Name | B-cell receptor CD22 precursor |
| Gene Name | Name: CD22 Synonyms:SIGLEC2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P20273 |
| PRO Name | B-cell receptor CD22 (human) |
| Definition | A B-cell receptor CD22 that is encoded in the genome of human. |
| Short Label | hCD22 |
| Category | organism-gene |
DAG ViewP20273 (CD22) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N61 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N65 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N67 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N99 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N101 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N112 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N135 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N231 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| K288 | Sumoylation | score1 | PhosphoSitePlus | |||
| N445 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N546 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N574 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N575 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| Y591 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N621 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N633 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N634 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| C695 | Methylation | score1 | IEDB | 31844290 | ||
| T715 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S717 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y762 | Phosphorylation | score3 | PRO PhosphoSitePlus RLIMS-P | 16393971 | ||
| Y796 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K801 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y807 | Phosphorylation | score4 | phospho.ELM PRO PhosphoSitePlus RLIMS-P | 16393971, 27125377 | ||
| Y822 | Phosphorylation | score4 | PRO PhosphoSitePlus RLIMS-P | 16393971, 27125377, 31019513 | ||
| Y842 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P | 16393971 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000046622 (hCD22/SigPep-/Phos:1) | pY762,pY807,pY822 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| N65 | K65 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| N67 | D67 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| N135 | S135 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| N135 | T135 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| N621 | S621 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| C695 | R695 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S717 | N717 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| Y842 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |
