Protein Information

Cytoscape View


UniProt AC / UniProt ID P20273 / CD22_HUMAN
Protein Name B-cell receptor CD22 precursor
Gene Name Name: CD22
Synonyms:SIGLEC2;
Organism Homo sapiens (Human)

PRO ID PR:P20273
DAG View
PRO Name B-cell receptor CD22 (human)
Definition A B-cell receptor CD22 that is encoded in the genome of human.
Short Label hCD22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20273 (CD22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N61 N-Glycosylation GlyGen 24190977
N65 N-Glycosylation GlyGen 24190977
N67 N-Glycosylation GlyGen 24190977
N99 N-Glycosylation GlyGen 24190977
N101 N-Glycosylation GlyGen 24190977
N112 N-Glycosylation GlyGen 24190977
N135 N-Glycosylation GlyGen 24190977
N231 N-Glycosylation GlyGen 24190977
K288 Sumoylation PhosphoSitePlus
N445 N-Glycosylation GlyGen 24190977
N546 N-Glycosylation GlyGen 24190977
N574 N-Glycosylation GlyGen 24190977
N575 N-Glycosylation GlyGen 24190977
Y591 Phosphorylation PhosphoSitePlus
N621 N-Glycosylation GlyGen 24190977
N633 N-Glycosylation GlyGen 24190977
N634 N-Glycosylation GlyGen 24190977
T715 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 16393971
Y796 Phosphorylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
Y807 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 16393971, 27125377
Y822 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 16393971, 27125377, 31019513
Y842 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 16393971


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046622 (hCD22/SigPep-/Phos:1) pY762,pY807,pY822 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N67 D67 Biomuta DOID:10283 / prostate cancer [ cosmic ]
N135 T135 Biomuta DOID:363 / uterine cancer [ tcga ]
N621 S621 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S717 N717 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]