iPTMnet Report for P20248 (CCNA2)
Protein Information
| UniProt AC / UniProt ID | P20248 / CCNA2_HUMAN |
| Protein Name | Cyclin-A2 |
| Gene Name | Name: CCNA2 Synonyms:CCN1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P20248 |
| PRO Name | cyclin-A2 (human) |
| Definition | A cyclin-A2 that is encoded in the genome of human. |
| Short Label | hCCNA2 |
| Category | organism-gene |
DAG ViewP20248 (CCNA2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Ubiquitination | score1 | PRO | ||||
| M1 | Acetylation | score1 | UniProt | 19369195 | ||
| S5 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 19369195, 23186163, 18691976 | ||
| K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K54 | Acetylation | score1 | PhosphoSitePlus | |||
| K54 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S55 | Phosphorylation | score2 | IEDB PhosphoSitePlus UniProt | 19369195, 28228285 | ||
| K68 | Acetylation | score1 | PhosphoSitePlus | |||
| K76 | Acetylation | score1 | PhosphoSitePlus | |||
| K91 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K95 | Acetylation | score1 | PhosphoSitePlus | |||
| K95 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K112 | Acetylation | score1 | PhosphoSitePlus | |||
| Y146 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S151 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S154 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P Signor | 10652300 | ||
| S154 | Phosphorylation | P24941 (CDK2) | score3 | PhosphoSitePlus Signor | 10652300 | |
| K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C193 | Methylation | score1 | IEDB | 31844290 | ||
| S209 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y225 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S244 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C327 | Methylation | score1 | IEDB | 31844290 | ||
| T380 | Phosphorylation | score0 | RLIMS-P | 10652300 | ||
| K388 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K400 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K417 | Ubiquitination | score1 | PhosphoSitePlus |
P20248 (CCNA2) as PTM Enzyme
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P06493 (CDK1) | Y15 | P20248 (CCNA2) | decreased_association | eFIP | 25664647 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000025750 (hCDKN1B/iso:1/Phos:2) | Interaction | PR:P20248 (hCCNA2) | PRO | 17254966 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K76 | T76 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K112 | E112 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| S154 | L154 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
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