iPTMnet Report for P20248 (CCNA2)
Protein Information
UniProt AC / UniProt ID | P20248 / CCNA2_HUMAN |
Protein Name | Cyclin-A2 |
Gene Name | Name: CCNA2 Synonyms:CCN1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P20248 |
PRO Name | cyclin-A2 (human) |
Definition | A cyclin-A2 that is encoded in the genome of human. |
Short Label | hCCNA2 |
Category | organism-gene |
P20248 (CCNA2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Ubiquitination | score1 | PRO | ||||
M1 | Acetylation | score1 | UniProt | 19369195 | ||
S5 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 19369195, 23186163, 18691976 | ||
K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
K54 | Acetylation | score1 | PhosphoSitePlus | |||
K54 | Ubiquitination | score1 | PhosphoSitePlus | |||
S55 | Phosphorylation | score2 | IEDB PhosphoSitePlus UniProt | 19369195, 28228285 | ||
K68 | Acetylation | score1 | PhosphoSitePlus | |||
K76 | Acetylation | score1 | PhosphoSitePlus | |||
K91 | Ubiquitination | score1 | PhosphoSitePlus | |||
K95 | Acetylation | score1 | PhosphoSitePlus | |||
K95 | Ubiquitination | score1 | PhosphoSitePlus | |||
K112 | Acetylation | score1 | PhosphoSitePlus | |||
Y146 | Phosphorylation | score0 | HPRD | 18691976 | ||
S151 | Phosphorylation | score0 | HPRD | 18691976 | ||
S154 | Phosphorylation | P24941 (CDK2) | score3 | PhosphoSitePlus RLIMS-P Signor | 10652300 | |
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
C193 | Methylation | score1 | IEDB | 31844290 | ||
S209 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y225 | Phosphorylation | score1 | PhosphoSitePlus | |||
S244 | Phosphorylation | score1 | PhosphoSitePlus | |||
C327 | Methylation | score1 | IEDB | 31844290 | ||
T380 | Phosphorylation | score0 | RLIMS-P | 10652300 | ||
K388 | Ubiquitination | score1 | PhosphoSitePlus | |||
K400 | Ubiquitination | score1 | PhosphoSitePlus | |||
K417 | Ubiquitination | score1 | PhosphoSitePlus |
P20248 (CCNA2) as PTM Enzyme
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P06493 (CDK1) | Y15 | P20248 (CCNA2) | decreased_association | eFIP | 25664647 |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:000025750 (hCDKN1B/iso:1/Phos:2) | Interaction | PR:P20248 (hCCNA2) | PRO | 17254966 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K76 | T76 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K112 | E112 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
S154 | L154 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |