iPTMnet Report for P19021 (PAM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19021 / AMD_HUMAN
Protein Name Peptidyl-glycine alpha-amidating monooxygenase precursor
Gene Name Name: PAM
Organism Homo sapiens (Human)

PRO ID PR:P19021
DAG View
PRO Name peptidyl-glycine alpha-amidating monooxygenase (human)
Definition A peptidyl-glycine alpha-amidating monooxygenase that is encoded in the genome of human.
Short Label hPAM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19021 (PAM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T35 O-Glycosylation GlyGen 25813380
T45 O-Glycosylation GlyGen 30459171
T46 O-Glycosylation GlyGen 30459171
K69 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
C126 Methylation IEDB 31844290
K396 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
T413 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
K415 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
S466 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T467 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S473 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K610 Ubiquitination PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
T836 Phosphorylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus   UniProt 23186163
S929 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 8530412
S934 Phosphorylation phospho.ELM 8530412
S942 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
T943 Phosphorylation PhosphoSitePlus   UniProt 10574929
S946 Phosphorylation Q8TAS1 (UHMK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10574929, 21406692, 17081983
S955 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S957 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
Site PTM Type PTM Enzyme Score Source PMID
S822 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S827 Phosphorylation P17252 (PRKCA) HPRD 8530412
S835 Phosphorylation HPRD 19651622, 17081983
T836 Phosphorylation HPRD 19651622, 17081983
S839 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S848 Phosphorylation HPRD 17081983
S850 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S861 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S866 Phosphorylation P17252 (PRKCA) HPRD 8530412
S874 Phosphorylation HPRD 19651622, 17081983
T875 Phosphorylation HPRD 19651622, 17081983
S878 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S887 Phosphorylation HPRD 17081983
S889 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S843 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S848 Phosphorylation P17252 (PRKCA) HPRD 8530412
S856 Phosphorylation HPRD 19651622, 17081983
T857 Phosphorylation HPRD 19651622, 17081983
S860 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S869 Phosphorylation HPRD 17081983
S871 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
K891 Acetylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
K902 Acetylation PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
S930 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S935 Phosphorylation P17252 (PRKCA) HPRD 8530412
S943 Phosphorylation HPRD 19651622, 17081983
T944 Phosphorylation HPRD 19651622, 17081983
S947 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S956 Phosphorylation HPRD 17081983
S958 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K432 N432 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S466 F466 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K819 R819 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K819 E819 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S822 G822 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S843 G843 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S848 N848 Biomuta DOID:4159 / skin cancer [ cosmic ]
S861 G861 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S869 N869 Biomuta DOID:4159 / skin cancer [ cosmic ]
S887 N887 Biomuta DOID:4159 / skin cancer [ cosmic ]
K901 N901 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S929 G929 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S955 N955 Biomuta DOID:4159 / skin cancer [ cosmic ]