Protein Information

Cytoscape View


UniProt AC / UniProt ID P19021 / AMD_HUMAN
Protein Name Peptidyl-glycine alpha-amidating monooxygenase precursor
Gene Name Name: PAM
Organism Homo sapiens (Human)

PRO ID PR:P19021
DAG View
PRO Name peptidyl-glycine alpha-amidating monooxygenase (human)
Definition A peptidyl-glycine alpha-amidating monooxygenase that is encoded in the genome of human.
Short Label hPAM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19021 (PAM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K69 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
T413 O-Glycosylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
S466 O-Glycosylation PhosphoSitePlus
T467 O-Glycosylation PhosphoSitePlus
S473 O-Glycosylation PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
T836 Phosphorylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus   UniProt 23186163
S929 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 8530412
S934 Phosphorylation phospho.ELM 8530412
S942 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
T943 Phosphorylation PhosphoSitePlus   UniProt 10574929
S946 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 10574929, 21406692, 17081983
S946 Phosphorylation Q8TAS1 (UHMK1) Signor 10574929
S955 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S957 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
Site PTM Type PTM Enzyme Score Source PMID
S822 Phosphorylation HPRD 18669648, 8530412
S822 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S827 Phosphorylation HPRD 8530412
S827 Phosphorylation P17252 (PRKCA) HPRD 8530412
S835 Phosphorylation HPRD 19651622, 17081983
T836 Phosphorylation HPRD 19651622, 17081983
S839 Phosphorylation HPRD 19651622, 10574929
S839 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S848 Phosphorylation HPRD 17081983
S850 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S861 Phosphorylation HPRD 18669648, 8530412
S861 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S866 Phosphorylation HPRD 8530412
S866 Phosphorylation P17252 (PRKCA) HPRD 8530412
S874 Phosphorylation HPRD 19651622, 17081983
T875 Phosphorylation HPRD 19651622, 17081983
S878 Phosphorylation HPRD 19651622, 10574929
S878 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S887 Phosphorylation HPRD 17081983
S889 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S843 Phosphorylation HPRD 18669648, 8530412
S843 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S848 Phosphorylation HPRD 8530412
S848 Phosphorylation P17252 (PRKCA) HPRD 8530412
S856 Phosphorylation HPRD 19651622, 17081983
T857 Phosphorylation HPRD 19651622, 17081983
S860 Phosphorylation HPRD 19651622, 10574929
S860 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S869 Phosphorylation HPRD 17081983
S871 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
K891 Acetylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
K902 Acetylation PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
S930 Phosphorylation HPRD 18669648, 8530412
S930 Phosphorylation P17252 (PRKCA) HPRD 18669648, 8530412
S935 Phosphorylation HPRD 8530412
S935 Phosphorylation P17252 (PRKCA) HPRD 8530412
S943 Phosphorylation HPRD 19651622, 17081983
T944 Phosphorylation HPRD 19651622, 17081983
S947 Phosphorylation HPRD 19651622, 10574929
S947 Phosphorylation Q8TAS1 (UHMK1) HPRD 19651622, 10574929
S956 Phosphorylation HPRD 17081983
S958 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K432 N432 Biomuta DOID:1324 / lung cancer [ tcga ]
S466 F466 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K819 R819 Biomuta DOID:1909 / melanoma [ cosmic ]
K819 E819 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K901 N901 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S946 I946 Biomuta DOID:3571 / liver cancer [ icgc ]