iPTMnet Report for P18074 (ERCC2)
Protein Information
UniProt AC / UniProt ID | P18074 / ERCC2_HUMAN |
Protein Name | General transcription and DNA repair factor IIH helicase subunit XPD |
Gene Name | Name: ERCC2 Synonyms:XPD,XPDC; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P18074 |
PRO Name | general transcription and DNA repair factor IIH helicase subunit XPD (human) |
Definition | A general transcription and DNA repair factor IIH helicase subunit XPD that is encoded in the genome of human. |
Short Label | hERCC2 |
Category | organism-gene |
P18074 (ERCC2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K29 | Ubiquitination | score1 | PhosphoSitePlus | |||
K35 | Ubiquitination | score1 | PhosphoSitePlus | |||
K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
K82 | Ubiquitination | score1 | PhosphoSitePlus | |||
K96 | Ubiquitination | score1 | PhosphoSitePlus | |||
K101 | Ubiquitination | score1 | PhosphoSitePlus | |||
K113 | Ubiquitination | score1 | PhosphoSitePlus | |||
T122 | Phosphorylation | score1 | PhosphoSitePlus | |||
K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
K133 | Ubiquitination | score1 | PhosphoSitePlus | |||
C155 | Methylation | score1 | IEDB | 31844290 | ||
K181 | Ubiquitination | score1 | PhosphoSitePlus | |||
K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
T252 | Phosphorylation | score1 | PhosphoSitePlus | |||
K268 | Ubiquitination | score1 | PhosphoSitePlus | |||
S296 | Phosphorylation | score1 | PhosphoSitePlus | |||
T425 | Phosphorylation | score1 | PhosphoSitePlus | |||
K507 | Ubiquitination | score1 | PhosphoSitePlus | |||
K565 | Ubiquitination | score1 | PhosphoSitePlus | |||
S578 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y584 | Phosphorylation | score1 | PhosphoSitePlus | |||
K603 | Ubiquitination | score1 | PhosphoSitePlus | |||
K671 | Ubiquitination | score1 | PhosphoSitePlus | |||
K682 | Ubiquitination | score1 | PhosphoSitePlus | |||
K718 | Ubiquitination | score1 | PhosphoSitePlus | |||
K751 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K69 | E69 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
K82 | N82 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K133 | E133 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
K181 | T181 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
S578 | I578 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y584 | H584 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K603 | T603 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
K671 | E671 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K682 | * | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
K751 | Q751 | Biomuta | [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ civic, cosmic ] DOID:184 / bone cancer [ civic ] DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] |