Protein Information

Cytoscape View


UniProt AC / UniProt ID P18074 / ERCC2_HUMAN
Protein Name General transcription and DNA repair factor IIH helicase subunit XPD
Gene Name Name: ERCC2
Synonyms:XPD,XPDC;
Organism Homo sapiens (Human)

PRO ID PR:P18074
DAG View
PRO Name general transcription and DNA repair factor IIH helicase subunit XPD (human)
Definition A general transcription and DNA repair factor IIH helicase subunit XPD that is encoded in the genome of human.
Short Label hERCC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18074 (ERCC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K113 N113 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K181 T181 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
K268 N268 Biomuta DOID:1324 / lung cancer [ tcga ]
K603 T603 Biomuta DOID:263 / kidney cancer [ tcga ]
K751 Q751 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1324 / lung cancer [ civic ] DOID:1115 / sarcoma [ civic ]