iPTMnet Report for P18031 (PTPN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P18031 / PTN1_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 1
Gene Name Name: PTPN1
Synonyms:PTP1B;
Organism Homo sapiens (Human)

PRO ID PR:P18031
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 1 (human)
Definition A tyrosine-protein phosphatase non-receptor type 1 that is encoded in the genome of human.
Short Label hPTPN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18031 (PTPN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 2546149
K5 Ubiquitination PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
Y20 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
C32 S-Nitrosylation dbSNO 18840608, 26338901, 22126794, ...22178444, 19483679
Y46 Phosphorylation PhosphoSitePlus
S50 Phosphorylation HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 11579209, 23186163, ...25398386, 10480872, 20615878
S50 Phosphorylation P31749 (AKT1) HPRD   neXtProt   PhosphoSitePlus 18691976, 11579209
S50 Phosphorylation P49759 (CLK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18691976, 11579209, 10480872
S50 Phosphorylation P49760 (CLK2) HPRD   neXtProt   PhosphoSitePlus   Signor 18691976, 11579209, 10480872
S55 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
Y66 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8999839, 9355745, 11106648, ...32098194, 11506178
Y66 Phosphorylation P00533 (EGFR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11106648, 11506178, 9355745
Y66 Phosphorylation P06213 (INSR) HPRD 11506178, 9355745
S70 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
C92 S-Nitrosylation dbSNO 18840608, 22178444
S104 O-Glycosylation GlyGen 26402673
K116 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
C121 Methylation IEDB 31844290
K128 Ubiquitination PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
Y152 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 11106648, 8999839, 11506178
Y152 Phosphorylation P06213 (INSR) HPRD   phospho.ELM 11106648, 11506178
Y153 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 11106648, 8999839, 11506178
Y153 Phosphorylation P06213 (INSR) HPRD   phospho.ELM 11106648, 11506178
S201 O-Glycosylation GlyGen 26402673
S201 Phosphorylation RLIMS-P 26402673
S205 Phosphorylation PhosphoSitePlus
C215 S-Nitrosylation dbSNO 17532511, 22178444, 18840608
S222 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S242 Phosphorylation HPRD   IntAct   neXtProt   PhosphoSitePlus   UniProt 10480872
S242 Phosphorylation P49759 (CLK1) HPRD   neXtProt   PhosphoSitePlus 10480872
S242 Phosphorylation P49760 (CLK2) HPRD   neXtProt   PhosphoSitePlus 10480872
S243 Phosphorylation HPRD   IntAct   neXtProt   PhosphoSitePlus   UniProt 10480872
S243 Phosphorylation P49759 (CLK1) HPRD   neXtProt   PhosphoSitePlus 10480872
S243 Phosphorylation P49760 (CLK2) HPRD   neXtProt   PhosphoSitePlus 10480872
K247 Ubiquitination PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 23348582
S286 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 23348582
S295 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983
K314 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K335 Sumoylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
K347 Sumoylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S352 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 9006942, ...9600099, 8491187, 7935344, 20068231
S352 Phosphorylation P19784 (CSNK2A2) HPRD 18691976, 9600099, 20068231
S352 Phosphorylation P68400 (CSNK2A1) HPRD 18691976, 9600099, 20068231
Y359 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus   UniProt 23186163
S365 Phosphorylation PhosphoSitePlus   UniProt 23186163
T368 Phosphorylation PhosphoSitePlus   UniProt 23186163
S378 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 8491187, 23186163, ...9600099
S378 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 8491187
S378 Phosphorylation P19784 (CSNK2A2) HPRD 9600099
S378 Phosphorylation P68400 (CSNK2A1) HPRD 9600099
R380 Methylation PhosphoSitePlus
S386 O-Glycosylation GlyGen 26402673
S386 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 9006942, 9600099, ...8491187, 23348582, 26402673
S386 Phosphorylation P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9600099, 8491187, 23348582
S386 Phosphorylation P19784 (CSNK2A2) HPRD 9600099, 8491187
S386 Phosphorylation P68400 (CSNK2A1) HPRD 9600099, 8491187
S393 Phosphorylation PhosphoSitePlus   RLIMS-P 23348582
S393 Phosphorylation P53350 (PLK1) PhosphoSitePlus 23348582
C426 Methylation IEDB 31844290


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P18031 (PTPN1) S50 P63104 (YWHAZ) unknown eFIP 31873221
Phosphorylation Q14449 (GRB14) Y347 P18031 (PTPN1) unknown eFIP 21791607


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025712 (hACTN1/iso:1/Phos:1) Interaction PR:P18031 (hPTPN1) PRO 16291744


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C32 G32 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y46 H46 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C92 R92 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K128 N128 Biomuta DOID:1324 / lung cancer [ cosmic ]
K131 I131 Biomuta DOID:1324 / lung cancer [ cosmic ]
S222 A222 Biomuta DOID:4159 / skin cancer [ cosmic ]
S295 F295 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S365 G365 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S365 R365 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R380 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S386 F386 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]