Protein Information

Cytoscape View


UniProt AC / UniProt ID P18031 / PTN1_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 1
Gene Name Name: PTPN1
Synonyms:PTP1B;
Organism Homo sapiens (Human)

PRO ID PR:P18031
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 1 (human)
Definition A tyrosine-protein phosphatase non-receptor type 1 that is encoded in the genome of human.
Short Label hPTPN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18031 (PTPN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 2546149
K5 Ubiquitination PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
Y20 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
C32 S-Nitrosylation dbSNO 18840608, 26338901, 22126794, ...22178444, 19483679
Y46 Phosphorylation PhosphoSitePlus
S50 Phosphorylation P31749 (AKT1) , P49760 (CLK2) , P49759 (CLK1) HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 11579209, 23186163, ...25398386, 10480872, 20615878
S55 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
Y66 Phosphorylation P00533 (EGFR) , P06213 (INSR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8999839, 9355745, 11106648, ...32098194, 11506178
S70 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
C92 S-Nitrosylation dbSNO 18840608, 22178444
K116 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
Y152 Phosphorylation P06213 (INSR) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 8999839, 11106648, 11506178, ...32061178, 33511306
Y153 Phosphorylation P06213 (INSR) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 11106648, 8999839, 11506178
S201 Phosphorylation RLIMS-P 26402673
S205 Phosphorylation PhosphoSitePlus
C215 S-Nitrosylation dbSNO 17532511, 22178444, 18840608
S222 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S242 Phosphorylation P49759 (CLK1) , P49760 (CLK2) HPRD   IntAct   neXtProt   PhosphoSitePlus   UniProt 10480872
S243 Phosphorylation P49759 (CLK1) , P49760 (CLK2) HPRD   IntAct   neXtProt   PhosphoSitePlus   UniProt 10480872
K247 Ubiquitination PhosphoSitePlus
S286 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P 23348582
S295 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983
K314 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K335 Sumoylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
K347 Sumoylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S352 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 9006942, ...9600099, 8491187, 7935344, 20068231
Y359 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus   UniProt 23186163
S365 Phosphorylation PhosphoSitePlus   UniProt 23186163
T368 Phosphorylation PhosphoSitePlus   UniProt 23186163
S378 Phosphorylation P68400 (CSNK2A1) , P17252 (PRKCA) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 8491187, 23186163, ...9600099
R380 Methylation PhosphoSitePlus
S386 Phosphorylation P06493 (CDK1) , P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 9006942, 9600099, ...8491187, 23348582, 26402673
S393 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P 23348582


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation E9PYG6 (Rasa1) Y451 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation O60674 (JAK2) Y1007 P18031 (PTPN1) unknown eFIP 21806020
Phosphorylation P04629 (NTRK1) Y681 P18031 (PTPN1) unknown eFIP 12237455
Phosphorylation P05556 (ITGB1) Y795 P18031 (PTPN1) unknown eFIP 21806020
Phosphorylation P05622 (Pdgfrb) Y762 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation P06213 (INSR) Y1185 P18031 (PTPN1) unknown eFIP 11163213
Phosphorylation P06213 (INSR) Y1189 P18031 (PTPN1) unknown eFIP 21806020
Phosphorylation P06213 (INSR) Y1190 P18031 (PTPN1) unknown eFIP 12237455
Phosphorylation P06213 (INSR) Y1190 P18031 (PTPN1) unknown eFIP 15588987
Phosphorylation P06213 (INSR) Y1185 P18031 (PTPN1) unknown eFIP 17481567
Phosphorylation P08922 (ROS1) Y2110 P18031 (PTPN1) unknown eFIP 17416557
Phosphorylation P12931 (SRC) Y530 P18031 (PTPN1) unknown eFIP 11007774
Phosphorylation P18031 (PTPN1) S50 P49759 (CLK1) unknown eFIP 10480872
Phosphorylation P18031 (PTPN1) S50 P49760 (CLK2) unknown eFIP 10480872
Phosphorylation P29376 (LTK) Y677 P18031 (PTPN1) unknown eFIP 12237455
Phosphorylation P30999 (Ctnnd1) Y280 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation P39447 (Tjp1) Y1164 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation P42229 (STAT5A) T684 P18031 (PTPN1) unknown eFIP 12237455
Phosphorylation P51692 (STAT5B) Y683 P18031 (PTPN1) unknown eFIP 12237455
Phosphorylation P56945 (BCAR1) Y165 P18031 (PTPN1) unknown eFIP 10889023
Phosphorylation P97465 (Dok1) Y376 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation Q01279 (Egfr) Y1197 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation Q14449 (GRB14) Y347 P18031 (PTPN1) unknown eFIP 21791607
Phosphorylation Q16288 (NTRK3) Y709 P18031 (PTPN1) unknown eFIP 12237455
Phosphorylation Q60598 (Cttn) Y421 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation Q62077 (Plcg1) Y771 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation Q6P549 (Inppl1) Y1136 P18031 (PTPN1) unknown eFIP 18515860
Phosphorylation Q8BFW7 (Lpp) Y302 P18031 (PTPN1) unknown eFIP 18515860


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025712 (hACTN1/iso:1/Phos:1) Interaction PR:P18031 (hPTPN1) PRO 16291744


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 N15 Biomuta DOID:2531 / hematologic cancer [ icgc ]
C32 G32 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y46 H46 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
C92 R92 Biomuta DOID:363 / uterine cancer [ tcga ]
S222 A222 Biomuta DOID:4159 / skin cancer [ icgc ]
S295 F295 Biomuta DOID:1909 / melanoma [ tcga ]
S365 G365 Biomuta DOID:363 / uterine cancer [ tcga ]
R380 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S386 F386 Biomuta DOID:1909 / melanoma [ icgc, tcga ]